[Effects of phenytoin on structural aberration of human sperm chromosomes in vitro]

[Effects of phenytoin on structural aberration of human sperm chromosomes in vitro] Research Abstract Details 

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[Effects of phenytoin on structural aberration of human sperm chromosomes in vitro] Abstract Text:

H Meng,F Zhang,X Gao,X Wang,D Li,X Cui,Z Wang,

OBJECTIVE: To detect the mutagenic effects of phenytoin on human sperm chromosomes. METHODS: The mutagenic effects of phenytoin at 10, 20 and 40 microgram/ml were tested by an in vitro testing system of human sperm chromosomes, with leomycin A5 as a positive control and mutagen-free solution as the blank control. RESULTS: The frequencies of sperm with structural chromosomal aberrations and breakages of sperm chromosomes in the groups of 10 microgram/ml, 20 microgram/ml and 40 ug/ml of phenytoin were all higher than those in the blank control, but only in the group of 40 ug/ml, the elevated frequencies were statistically significant (P<0.005, P<0.05). CONCLUSION: Phenytoin has probably mutagenic potential effect on human sperm cells.

[Effects of phenytoin on structural aberration of human sperm chromosomes in vitro] Publishing Authors By Initials

H Meng,F Zhang,X Gao,X Wang,D Li,X Cui,Z Wang,

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[Effects of phenytoin on structural aberration of human sperm chromosomes in vitro] Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Zhonghua yi xue yi chuan xue za zhi = Zhonghua yix

VOLUME: 18

Page Numbers: 303-5

Journal Abbreviation: Zhonghua Yi Xue Yi Chuan Xue Z

ISSN: 1003-9406

DAY: 2

MONTH: Aug

YEAR: 2001

[Effects of phenytoin on structural aberration of human sperm chromosomes in vitro] Information

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LANGUAGE: chi

NlmUniqueID: 9425197

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AFFILIATION: Department of Psychiatry, the First Affiliated Hospital, Chongqing University of Medical Sciences, Chongqing 400016 P.R.China. MHQ99666@sina.com

Country: China

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MEDLINETA: Zhonghua Yi Xue Yi Chuan Xue Z

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