Effects of peroxisome proliferator-activated receptor-gamma agonists on central nervous system inflammation.

Effects of peroxisome proliferator-activated receptor-gamma agonists on central nervous system inflammation. Research Abstract Details 

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Effects of peroxisome proliferator-activated receptor-gamma agonists on central nervous system inflammation. Abstract Text:

Peroxisome proliferator-activated receptor-gamma (PPAR-gamma) plays a critical role in glucose and lipid metabolism. More recently, PPAR-gamma ligands have been reported to inhibit the expression of proinflammatory molecules by monocytes/macrophages. Of relevance to CNS disease is that PPAR-gamma agonists have been demonstrated to have similar effects on microglia. PPAR-gamma agonists also ameliorate experimental autoimmune encephalomyelitis, an animal model of multiple sclerosis. This Mini-Review summarizes the effects of PPAR-gamma agonists in mediating immune responses and the potential of these agonists in the treatment of inflammatory disorders of the CNS.

Effects of peroxisome proliferator-activated receptor-gamma agonists on central nervous system inflammation. Publishing Authors By Initials

For similar proteins: transcription factors research abstracts see: proteins: transcription factors research

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Effects of peroxisome proliferator-activated receptor-gamma agonists on central nervous system inflammation. Journal Published:

PUBLICATION TYPE: Review

Journal: Journal of neuroscience research

VOLUME: 71

Page Numbers: 315-25

Journal Abbreviation: J. Neurosci. Res.

ISSN: 0360-4012

DAY: 1

MONTH: Feb

YEAR: 2003

Effects of peroxisome proliferator-activated receptor-gamma agonists on central nervous system inflammation. Information

Number of References: 85

LANGUAGE: eng

NlmUniqueID: 7600111

Effects of peroxisome proliferator-activated receptor-gamma agonists on central nervous system inflammation. Keywords Mesh Terms:

KEYWORDS: Transcription Factors

MESH TERMS: metabolism

Chemical & Substance for Abstract: Effects of peroxisome proliferator-activated receptor-gamma agonists on central nervous system inflammation. Information

Substance Name: Transcription Factors

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Grant and Affiliation Information for Effects of peroxisome proliferator-activated receptor-gamma agonists on central nervous system inflammation.

AFFILIATION: Department of Anatomy and Neurobiology, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA.

Country: United States

AGENCY: United States NINDS

GRANT: R01 NS042860-01A1

ACRONYM: NS

MEDLINETA: J Neurosci Res

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