Effects of paraventricular nucleus lesions on chronic renal hypertension.

Effects of paraventricular nucleus lesions on chronic renal hypertension. Research Abstract Details 

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Effects of paraventricular nucleus lesions on chronic renal hypertension. Abstract Text:

The contribution of the paraventricular nucleus region of the hypothalamus (PVN) to the maintenance of one-kidney, figure-8 renal wrap hypertension was determined in this study. Electrolytic ablation of the PVN was performed 4 wk after the production of hypertension or sham operation. Ablation of the PVN region significantly reduced mean arterial pressure (MAP) from 150 +/- 9 to 110 +/- 3 mmHg in the hypertensive rats. In the sham-hypertensive group, the lesion decreased MAP from 118 +/- 2 to 99 +/- 4 mmHg. In both groups of animals MAP from 118 +/- 2 to 99 +/- 4 mmHg. In both groups of animals MAP returned to prelesion values by day 7 postlesion. When ganglionic blockade was performed on day 7 postlesion, the fall in MAP was greater in hypertensive rats (-44 +/- 5 mmHg) than in normotensive rats (-26 +/- 3 mmHg). In a separate group of rats studied 3 days after PVN ablation, ganglionic blockade produced similar decreases in MAP in the wrapped and sham-operated animals. These studies suggest that the PVN contributes to the increased functional sympathetic nervous system associated with one-kidney, figure-8 renal hypertension. Although ablation of the PVN region decreases MAP, neural mechanisms compensate to return MAP to hypertensive levels.

Effects of paraventricular nucleus lesions on chronic renal hypertension. Publishing Authors By Initials

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Effects of paraventricular nucleus lesions on chronic renal hypertension. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: The American journal of physiology

VOLUME: 261

Page Numbers: H860-7

Journal Abbreviation: Am. J. Physiol.

ISSN: 0002-9513

DAY: 16

MONTH: Sep

YEAR: 1991

Effects of paraventricular nucleus lesions on chronic renal hypertension. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 370511

Effects of paraventricular nucleus lesions on chronic renal hypertension. Keywords Mesh Terms:

KEYWORDS: Sympathetic Nervous System

MESH TERMS: physiopathology

Chemical & Substance for Abstract: Effects of paraventricular nucleus lesions on chronic renal hypertension. Information

Substance Name: Sodium

Registry Number: 7440-23-5

Grant and Affiliation Information for Effects of paraventricular nucleus lesions on chronic renal hypertension.

AFFILIATION: Department of Pharmacology, University of Texas Health Science Center, San Antonio 78284-7764.

Country: UNITED STATES

AGENCY: United States NHLBI

GRANT: HL-36080

ACRONYM: HL

MEDLINETA: Am J Physiol

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