Effects of organochlorine pesticides on interleukin secretion from lymphocytes.

Effects of organochlorine pesticides on interleukin secretion from lymphocytes. Research Abstract Details 

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Effects of organochlorine pesticides on interleukin secretion from lymphocytes. Abstract Text:

T M Beach,M M Whalen,

Organochlorine pesticides have been used worldwide primarily as insecticides. Due to their chemical stability, they often persist in the environment long after their use has ceased. In a previous study, we found that six organochlorine compounds (alpha-chlordane, gamma-chlordane, 4,4'-DDT, heptachlor, oxychlordane, and pentachlorophenol (PCP)), at concentrations of 5 microM, were able to significantly decrease the ability of highly purified human natural killer (NK) cells to lyse tumor cells after exposures, ranging from 1 hour to 6 days. However, if T cells were present with the NK cells (T/NK cells), loss of lytic function was seen only with oxychlordane and PCP. The purpose of the current study is to begin to investigate the mechanism by which T cells may be blocking the negative effects of some organochlorine compounds on NK cell function. Here, we investigated the hypothesis that T cells could produce significant levels of NK-stimulatory interleukin(s) (ILs), and that this may account for the decreased inhibition seen with organochlorine exposures when T cells were present. Secretion of four cytokines that have a demonstrated capacity to influence NK function, and/or are secreted by T cells, was measured (IL-2, IL-4, IL-10, IL-12). We measured both the baseline levels of ILs and the effects of organochlorine compound on IL secretion in T/NK cells. The results showed that baseline levels of the NK-stimulatory IL, IL-12, were 898 +/- 264 pg/mL at 24 hours and IL-10 levels were 564 +/- 337 pg/mL. In contrast, IL-2 levels were 14 +/- 10 pg/mL, and IL-4 levels were 3 +/- 2 pg/mL at 24 hours. The two compounds that retained their capacity to decrease NK lytic function in T/NK cells, oxychlordane (5 microM) and PCP (5 and 10 microM), were able to either decrease the secretion of NK-stimulatory ILs (IL-2, IL-12 and/or IL-10) and/or increase secretion of the NK-inhibitory cytokine, IL-4, at each length of exposure tested.

Effects of organochlorine pesticides on interleukin secretion from lymphocytes. Publishing Authors By Initials

TM Beach,MM Whalen,

For similar cells: blood cells: leukocytes: leukocytes, mononuclear: lymphocytes: t-lymphocytes research abstracts see: cells: blood cells: leukocytes: leukocytes, mononuclear: lymphocytes: t-lymphocytes research

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Effects of organochlorine pesticides on interleukin secretion from lymphocytes. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Human & experimental toxicology

VOLUME: 25

Page Numbers: 651-9

Journal Abbreviation:

ISSN: 0960-3271

DAY: 3

MONTH: Nov

YEAR: 2006

Effects of organochlorine pesticides on interleukin secretion from lymphocytes. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9004560

Effects of organochlorine pesticides on interleukin secretion from lymphocytes. Keywords Mesh Terms:

KEYWORDS: T-Lymphocytes

MESH TERMS: metabolism

Chemical & Substance for Abstract: Effects of organochlorine pesticides on interleukin secretion from lymphocytes. Information

Substance Name: Pesticides

Registry Number: 0

Grant and Affiliation Information for Effects of organochlorine pesticides on interleukin secretion from lymphocytes.

AFFILIATION: Department of Chemistry, Tennessee State University, Nashville, TN 37209, USA.

Country: England

AGENCY: United States NIGMS

GRANT: 2S06GM08092-28

ACRONYM: GM

MEDLINETA: Hum Exp Toxicol

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