Effects of nicotinic therapies on attention and executive functions in chronic low-dose MPTP-treated monkeys.

Effects of nicotinic therapies on attention and executive functions in chronic low-dose MPTP-treated monkeys. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Effects of nicotinic therapies on attention and executive functions in chronic low-dose MPTP-treated monkeys. Abstract Text:

E Decamp,J S Schneider,

Chronic administration of low doses of the neurotoxin MPTP to nonhuman primates induces cognitive deficits similar to those seen in early Parkinson's disease (PD) patients, without the confounding effect of significant motor impairment. The present study assessed the extent to which specific attentional and central executive deficits in chronic low dose (CLD) MPTP-treated monkeys could be modified by nicotinic therapies. Four adult male rhesus monkeys were trained to perform attention and executive function tasks and were then administered low doses of MPTP (dose range: 0.025-0.1 mg/kg, i.v.) over 98-158 days until stable cognitive deficits appeared. Results showed that both nicotine and the alpha4beta4 subtype-selective nAChR agonist SIB-1553A could improve certain aspects of attentional and central executive functioning in this model of early Parkinsonism. Nicotine failed to improve performance of CLD-MPTP-treated animals on an attention set-shifting task while SIB-1553A significantly improved at least some aspects of performance, suggesting that the compound increased the animals' ability to maintain a previously formed response set and restored cognitive flexibility. Both nicotine and SIB-1553A caused a dose-dependent enhancement of performance on the focused attention (cued reaction time) task, decreasing reaction times on both cued and noncued trials. Nicotine caused a significant reduction in reaction times but did not alter the error profile on an impulse (motor readiness) task. SIB-1553A reduced reaction times but caused an increase in bar release (i.e. impulsivity) errors. These data suggest that nicotinic drugs may have therapeutic potential for treating cognitive dysfunction in PD.

Effects of nicotinic therapies on attention and executive functions in chronic low-dose MPTP-treated monkeys. Publishing Authors By Initials

E Decamp,JS Schneider,

For similar reaction time research abstracts see: reaction time research

PUBMED ID PMID:

MEDLINE DATE:

Effects of nicotinic therapies on attention and executive functions in chronic low-dose MPTP-treated monkeys. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: The European journal of neuroscience

VOLUME: 24

Page Numbers: 2098-104

Journal Abbreviation: Eur. J. Neurosci.

ISSN: 0953-816X

DAY: 3

MONTH: Oct

YEAR: 2006

Effects of nicotinic therapies on attention and executive functions in chronic low-dose MPTP-treated monkeys. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8918110

Effects of nicotinic therapies on attention and executive functions in chronic low-dose MPTP-treated monkeys. Keywords Mesh Terms:

KEYWORDS: Reaction Time

MESH TERMS: drug effects

Chemical & Substance for Abstract: Effects of nicotinic therapies on attention and executive functions in chronic low-dose MPTP-treated monkeys. Information

Substance Name: Nicotine

Registry Number: 54-11-5

Grant and Affiliation Information for Effects of nicotinic therapies on attention and executive functions in chronic low-dose MPTP-treated monkeys.

AFFILIATION: Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, 1020 Locust Street, 521 JAH, Philadelphia, PA 19107, USA.

Country: France

AGENCY: United States NIDA

GRANT: DA013452

ACRONYM: DA

MEDLINETA: Eur J Neurosci

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Effects of nicotinic therapies on attention and executive functions in chronic low-dose MPTP-treated monkeys Related Publications

• A superconductive undulator with a period length of 3.8 mm.
• Abstinence and acceptance? The problematic relationship between the German abstinence paradigm, low-threshold oriented drug work, and methadone.
• Acarbose, a pseudooligosaccharide, is transported but not metabolized by the maltose-maltodextrin system of Escherichia coli.
• Akt and FOXO dysregulation contribute to infection-induced wasting in Drosophila.
• All my rights.
• Articular cartilage repair by gene therapy using growth factor-producing mesenchymal cells.
• Bone regeneration in critical size defects by cell-mediated BMP-2 gene transfer: a comparison of adenoviral vectors and liposomes.
• Calcium transients and intramembrane charge movement in skeletal muscle fibres.
• Cell size and Cln-Cdc28 complexes mediate entry into meiosis by modulating cell growth.
• Chest CT findings in pediatric Wegener's granulomatosis.
• Development of ATD Installation Procedures Based on Rear-Seat Occupant Postures.
• Does attention alter appearance?
• Dynamic modulation of upper airway function during sleep: a novel single-breath method.
• Effect of electrostatic interactions on binding and retention of DNA oligomers to PNA liposomes assessed by FRET measurements.
• Effects of nicotinic therapies on attention and executive functions in chronic low-dose MPTP-treated monkeys.
• Endotoxic shock in AUF1 knockout mice mediated by failure to degrade proinflammatory cytokine mRNAs.
• Estimating infant head injury criteria and impact response using crash reconstruction and finite element modeling.
• Evidence for cortical dysfunction and widespread manganese accumulation in the nonhuman primate brain following chronic manganese exposure: a 1H-MRS and MRI study.
• Fibroblast-mediated delivery of growth factor complementary DNA into mouse joints induces chondrogenesis but avoids the disadvantages of direct viral gene transfer.
• Influence of day of collection on recovery rate in mature cycling mares.
• Influence of intensive embryo collection on subsequent embryo production.
• Influence of vesicle curvature on fluorescence relaxation kinetics of fluorophores.
• Metabolic and hormonal control of the desire for food and sex: implications for obesity and eating disorders.
• Nigrostriatal dopamine system dysfunction and subtle motor deficits in manganese-exposed non-human primates.
• Perceived barriers to walking for physical activity.
• Shigella as a foodborne pathogen and current methods for detection in food.
• The effects of tethering rear -facing child restraint systems on atd responses.
• The tolerance of the human hip to dynamic knee loading.
• [Evidence-based guidelines - what is the present situation?]
• [Innovative imaging in urology: fascination and future : Yesterday, today, and tomorrow.]