Effects of nalbuphine on anterior pituitary and adrenal hormones and subjective responses in male cocaine abusers.

Effects of nalbuphine on anterior pituitary and adrenal hormones and subjective responses in male cocaine abusers. Research Abstract Details 

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Effects of nalbuphine on anterior pituitary and adrenal hormones and subjective responses in male cocaine abusers. Abstract Text:

Nathalie V Goletiani,Jack H Mendelson,Michelle B Sholar,Arthur J Siegel,Alicja Skupny,Nancy K Mello,Nathalie V Goletiani,Jack H Mendelson,Michelle B Sholar,Arthur J Siegel,Alicja Skupny,Nancy K Mello,

Nalbuphine (Nubain) is a mixed action mu-kappa agonist used clinically for the management of pain. Nalbuphine and other mu-kappa agonists decreased cocaine self-administration in preclinical models. Cocaine stimulates the hypothalamic-pituitary-adrenal (HPA) axis, but the effects of nalbuphine on the HPA axis are unknown. Analgesic doses (5 and 10 mg/70 kg) of IV nalbuphine were administered to healthy male cocaine abusers, and plasma levels of PRL, ACTH and cortisol were measured before and at 10, 17, 19, 23, 27, 31, 35, 40, 45, 60, 75, 105, and 135 min after nalbuphine administration. Subjective effects were measured on a Visual Analog Scale (VAS). Prolactin (PRL) increased significantly within 17 min (P=.04) and reached peak levels of 22.1+/-7.1 ng/ml and 54.1+/-11.3 at 60 min after low and high dose nalbuphine administration, respectively. VAS reports of "Sick," "Bad" and "Dizzy" were significantly higher after 10 mg/70 kg than after 5 mg/70 kg nalbuphine (P=.05-.0001), and were significantly correlated with increases in PRL (P=.05-.0003). However, sedation and emesis were observed only after a 10 mg/70 kg dose of nalbuphine. Interestingly, ACTH and cortisol levels did not change significantly after administration of either dose of nalbuphine. Taken together, these data suggest that nalbuphine had both mu- and kappa-like effects on PRL (PRL increase) but did not increase ACTH and cortisol.

Effects of nalbuphine on anterior pituitary and adrenal hormones and subjective responses in male cocaine abusers. Publishing Authors By Initials

NV Goletiani,JH Mendelson,MB Sholar,AJ Siegel,A Skupny,NK Mello,NV Goletiani,JH Mendelson,MB Sholar,AJ Siegel,A Skupny,NK Mello,

For similar proteins: membrane proteins: receptors, cell surface: receptors, g-protein-coupled: receptors, opioid: receptors, opioid, mu research abstracts see: proteins: membrane proteins: receptors, cell surface: receptors, g-protein-coupled: receptors, opioid: receptors, opioid, mu research

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Effects of nalbuphine on anterior pituitary and adrenal hormones and subjective responses in male cocaine abusers. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Pharmacology, biochemistry, and behavior

VOLUME: 86

Page Numbers: 667-77

Journal Abbreviation: Pharmacol. Biochem. Behav.

ISSN: 0091-3057

DAY: 20

MONTH: 02

YEAR: 2007

Effects of nalbuphine on anterior pituitary and adrenal hormones and subjective responses in male cocaine abusers. Information

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LANGUAGE: eng

NlmUniqueID: 367050

Effects of nalbuphine on anterior pituitary and adrenal hormones and subjective responses in male cocaine abusers. Keywords Mesh Terms:

KEYWORDS: Receptors, Opioid, mu

MESH TERMS: physiology

Chemical & Substance for Abstract: Effects of nalbuphine on anterior pituitary and adrenal hormones and subjective responses in male cocaine abusers. Information

Substance Name: Prolactin

Registry Number: 9002-62-4

Grant and Affiliation Information for Effects of nalbuphine on anterior pituitary and adrenal hormones and subjective responses in male cocaine abusers.

AFFILIATION: Alcohol and Drug Abuse Research Center, Harvard Medical School, McLean Hospital, Belmont, MA 02478, USA. ngoletiani@mclean.harvard.edu

Country: United States

AGENCY: United States NIDA

GRANT: P01-DA14528

ACRONYM: DA

MEDLINETA: Pharmacol Biochem Behav

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