Effects of mycophenolic acid on high glucose-induced expression of TGF-beta and CTGF in mesangial cells.

Effects of mycophenolic acid on high glucose-induced expression of TGF-beta and CTGF in mesangial cells. Research Abstract Details 

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Effects of mycophenolic acid on high glucose-induced expression of TGF-beta and CTGF in mesangial cells. Abstract Text:

Yongman ,Junying Chen,Jufang Shao,

The effects of mycophenolic acid (MPA) on high glucose-induced expression of transforming growth factor-beta (TGF-beta) and connective tissue growth factor (CTGF) in mesangial cells (MC) were investigated. Rat MC were cultured in the presence of different concentrations of MPA (1.0 and 10.0 micromol/L) or MPA plus high glucose for 72 h. The expression of TGF-beta and CTGF was detected by Western blot. The results showed that high glucose could induce the expression of TGF-beta and CTGF in MC, but MPA could inhibit this effects. MPA did not influence the expression of TGF-beta and CTGF in normal glucose. It was concluded that MPA might prevent the progression of diabetic nephropathy by inhibiting the expression of TGF-beta and CTGF in MC.

Effects of mycophenolic acid on high glucose-induced expression of TGF-beta and CTGF in mesangial cells. Publishing Authors By Initials

Y ,J Chen,J Shao,

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Effects of mycophenolic acid on high glucose-induced expression of TGF-beta and CTGF in mesangial cells. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Journal of Huazhong University of Science and Tech

VOLUME: 26

Page Numbers: 292-3, 304

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ISSN: 1672-0733

DAY: 11

MONTH: 09

YEAR: 2006

Effects of mycophenolic acid on high glucose-induced expression of TGF-beta and CTGF in mesangial cells. Information

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LANGUAGE: eng

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Grant and Affiliation Information for Effects of mycophenolic acid on high glucose-induced expression of TGF-beta and CTGF in mesangial cells.

AFFILIATION: Department of Nephrology, Tongji Hospital, Huazhong University of Science and Technology, Wuhan 430030, China.

Country: China

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MEDLINETA: J Huazhong Univ Sci Technolog

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