Effects of morphine, fentanyl and tramadol on human immune response.

Effects of morphine, fentanyl and tramadol on human immune response. Research Abstract Details 

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Effects of morphine, fentanyl and tramadol on human immune response. Abstract Text:

Zhihen Liu,Feng Gao,Yuke Tian,

Morphine has been reported to suppress human immune response. We aimed to observe the effects of morphine, fentanyl and tramadol on NF-kappa B and IL-2 from both laboratory and clinical perspective. Jurkat cells were incubated with ten times clinically relevant concentrations of morphine, fentanyl and tramadol before being stimulated with PMA. NF-kappa B binding activity and IL-2 levels were measured. In the clinical study, 150 consenting patients were randomized into 3 groups according to the analgesics used in them, namely, group morphine (M), group fentanyl (F) and group tramadol (T). IL-2 was measured preoperatively and 1, 3 and 24 h after operation. Consequently, NF-kappa B activation was suppressed by morphine and fentanyl but not by tramadol. IL-2 was significantly decreased by morphine and fentanyl but not by tramadol in vitro. In the PCA patients, IL-2 was decreased in group M and increased in group F postoperatively. Whereas in group T, IL-2 was unchanged 1 h after operation but was significantly elevated 3 and 24 h after operation. Our results showed that the inhibition of morphine on IL-2 was most probably related to its suppression on NF-kappa B. Fentanyl had different effects on human immune response in vitro and in vivo. Tramadol may have immune enhancing effect.

Effects of morphine, fentanyl and tramadol on human immune response. Publishing Authors By Initials

Z Liu,F Gao,Y Tian,

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Effects of morphine, fentanyl and tramadol on human immune response. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Journal of Huazhong University of Science and Tech

VOLUME: 26

Page Numbers: 478-81

Journal Abbreviation: J. Huazhong Univ. Sci. Technol

ISSN: 1672-0733

DAY: 22

MONTH: 11

YEAR: 2006

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LANGUAGE: eng

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Grant and Affiliation Information for Effects of morphine, fentanyl and tramadol on human immune response.

AFFILIATION: Department of Anesthesiology, Tongji Hospital, Huazhong University of Science and Technology, Wuhan 430030, China.

Country: China

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MEDLINETA: J Huazhong Univ Sci Technolog

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