Effects of monensin on tropoelastin metabolism in vascular smooth muscle cells: monensin causes intracellular degradation of accumulated tropoelastin.

Effects of monensin on tropoelastin metabolism in vascular smooth muscle cells: monensin causes intracellular degradation of accumulated tropoelastin. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Effects of monensin on tropoelastin metabolism in vascular smooth muscle cells: monensin causes intracellular degradation of accumulated tropoelastin. Abstract Text:

K Ikeda,H Wachi,Y Seyama,S Tajima,

Treatment with 80 nM monensin for 48 h resulted in impairment of tropoelastin secretion during the initial 6 h and subsequent reduction of tropoelastin synthesis from 18 to 48 h to one-tenth. The steady state level of tropoelastin mRNA started to decrease at 6 h and reached one-fifth of the control level by 48 h. A pulse-chase experiment after 24 h monensin treatment demonstrated that half of the accumulated tropoelastin in the cells was rapidly degraded within 120 min. These results indicate that the marked reduction in tropoelastin synthesis from 6 to 48 h treatment may be caused by both a reduction in the tropoelastin mRNA level and accelerated intracellular degradation of tropoelastin. Thus, monensin modulates tropoelastin expression through pretranslational and posttranslational mechanisms.

Effects of monensin on tropoelastin metabolism in vascular smooth muscle cells: monensin causes intracellular degradation of accumulated tropoelastin. Publishing Authors By Initials

K Ikeda,H Wachi,Y Seyama,S Tajima,

For similar proteins: protein precursors: tropoelastin research abstracts see: proteins: protein precursors: tropoelastin research

PUBMED ID PMID:

MEDLINE DATE:

Effects of monensin on tropoelastin metabolism in vascular smooth muscle cells: monensin causes intracellular degradation of accumulated tropoelastin. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Journal of biochemistry

VOLUME: 121

Page Numbers: 5-7

Journal Abbreviation: J. Biochem.

ISSN: 0021-924X

DAY: 19

MONTH: Jan

YEAR: 1997

Effects of monensin on tropoelastin metabolism in vascular smooth muscle cells: monensin causes intracellular degradation of accumulated tropoelastin. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 376600

Effects of monensin on tropoelastin metabolism in vascular smooth muscle cells: monensin causes intracellular degradation of accumulated tropoelastin. Keywords Mesh Terms:

KEYWORDS: Tropoelastin

MESH TERMS: metabolism

Chemical & Substance for Abstract: Effects of monensin on tropoelastin metabolism in vascular smooth muscle cells: monensin causes intracellular degradation of accumulated tropoelastin. Information

Substance Name: Monensin

Registry Number: 17090-79-8

Grant and Affiliation Information for Effects of monensin on tropoelastin metabolism in vascular smooth muscle cells: monensin causes intracellular degradation of accumulated tropoelastin.

AFFILIATION: Department of Dermatology, National Defense Medical College, Saitama.

Country: JAPAN

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: J Biochem

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Effects of monensin on tropoelastin metabolism in vascular smooth muscle cells: monensin causes intracellular degradation of accumulated tropoelastin Related Publications

• Absence of residual quasiparticle conductivity in the underdoped cuprate YBa2Cu4O8.
• CYP2E1 Rsa I polymorphism impacts on risk of colorectal cancer association with smoking and alcohol drinking.
• Demonstration of laser-frequency upshift by electron-density modulations in a plasma wakefield.
• Distinct DNA methylation activity of Dnmt3a and Dnmt3b towards naked and nucleosomal DNA.
• Distinct enzymatic properties of recombinant mouse DNA methyltransferases Dnmt3a and Dnmt3b.
• Effects of monensin on tropoelastin metabolism in vascular smooth muscle cells: monensin causes intracellular degradation of accumulated tropoelastin.
• Exogenous expression of mouse Dnmt3 induces apoptosis in Xenopus early embryos.
• Expression cloning of a variety of novel protein kinases in Lotus japonicus.
• Flow-injection EPR investigation on oh radical scavenging activity of Gd(III) containing MRI contrast media.
• Gastric Cancer Risk and Erythrocyte Composition of Docosahexaenoic Acid with Anti-inflammatory Effects.
• Genetic association of glutathione peroxidase-1 with coronary artery calcification in type 2 diabetes: a case control study with multi-slice computed tomography.
• Identification of nondisulfided pro alpha 1 (IV) chain produced by cultured B16 melanoma cells.
• In vitro and Pathological Investigations of MODY5 with the R276X-HNF1beta (TCF2) Mutation.
• Inhibition of elastin synthesis by high potassium salt is mediated by Ca2+ influx in cultured smooth muscle cells in vitro: reciprocal effects of K+ on elastin and collagen synthesis.
• Involvement of the Rho/Rho Kinase Signaling Pathway in Platelet-Derived Growth Factor BB-induced Vascular Endothelial Growth Factor Expression in Diabetic Rat Retina.
• Is pubertal onset a risk factor for blindness and renal replacement therapy in childhood-onset type 1 diabetes in Japan?
• Isolation and expression of a Xenopus laevis DNA methyltransferase cDNA.
• Mechanisms of stimulation of collagen synthesis during chick embryonic skin development.
• Metabolic syndrome in youths.
• Modulation of elastin expression by heparin is dependent on the growth condition of vascular smooth muscle cells: up-regulation of elastin expression by heparin in the proliferating cells is mediated by the inhibition of protein kinase C activity.
• Modulations of elastin expression and cell proliferation by retinoids in cultured vascular smooth muscle cells.
• Proliferation of HSP47-positive skin fibroblasts in dermatofibroma.
• Ratio of high-, medium-, and low-molecular weight serum adiponectin to the total adiponectin value in children.
• Record low-power all-optical semiconductor switch operation at ultrafast repetition rates above the carrier cutoff frequency.
• Special section: policy perspectives.
• Stimulation effect of Dnmt3L on the DNA methylation activity of Dnmt3a2.
• Trafficking of green fluorescent protein-tagged SNARE proteins in HSY cells.
• Type II collagen accumulation in overlying dermo-epidermal junction of pilomatricoma is mediated by bone morphogenetic protein 2 and 4.
• Xenopus eggs express an identical DNA methyltransferase, Dnmt1, to somatic cells.
• Xenopus maintenance-type DNA methyltransferase is accumulated and translocated into germinal vesicles of oocytes.