Effects of modest testosterone supplementation and exercise for 12 weeks on body composition and quality of life in elderly men.

Effects of modest testosterone supplementation and exercise for 12 weeks on body composition and quality of life in elderly men. Research Abstract Details 

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Effects of modest testosterone supplementation and exercise for 12 weeks on body composition and quality of life in elderly men. Abstract Text:

Laurence Katznelson,Mara W Robinson,Caryn L Coyle,Hang Lee,Christina E Farrell,

OBJECTIVE: One of the factors that may promote deterioration in quality of life and body composition in elderly men is the relative decline in serum testosterone levels with aging. In this study, we assessed the effects of modest doses of testosterone and a home-based strengthening program on quality of life and body composition in elderly men with relative testosterone insufficiency. DESIGN: Double-blind, placebo-controlled randomized study (testosterone), and additional randomization to a resistance exercise program or no additional exercise for 12 weeks in men between ages of 65 and 85 years with relative testosterone insufficiency. METHODS: Seventy sedentary, community dwelling men were randomized to a 5 mg testoderm transdermal system applied daily vs placebo system, and additionally randomized to a home-based resistance exercise program. Subjects were randomized to Group 1 (testosterone plus exercise), Group 2 (testosterone plus no exercise), Group 3 (placebo plus exercise), and Group 4 (placebo plus no exercise). Endpoints included quality of life (assessed by the short form-36 questionnaire) and body composition (measured by dual x-ray absorptiometry scan). RESULTS: Serum testosterone increased by a mean of 10.0 +/- 1.9, 6.6 +/- 1.6, 0.52 +/- 0.6, and 0.5 +/- 0.6 nmol/l in Groups 1, 2, 3, and 4 respectively. There was a significant interaction of testosterone and exercise on quality of life in the domains of physical functioning (P = 0.03), role physical (P = 0.01), general health (P = 0.049), and social functioning (P = 0.04). There were no effects of testosterone or exercise on quality of life alone, nor in body composition parameters. CONCLUSIONS: Modest testosterone supplementation to elderly men with relative testosterone insufficiency improved quality of life when accompanied by an exercise program. The combination of testosterone and exercise may be an important strategy in the elderly, though further studies are necessary to determine the long-term impact on body composition and function and for analysis of risk/benefit ratios as well.

Effects of modest testosterone supplementation and exercise for 12 weeks on body composition and quality of life in elderly men. Publishing Authors By Initials

L Katznelson,MW Robinson,CL Coyle,H Lee,CE Farrell,

For similar diagnosis: prognosis: treatment outcome research abstracts see: diagnosis: prognosis: treatment outcome research

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Effects of modest testosterone supplementation and exercise for 12 weeks on body composition and quality of life in elderly men. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: European journal of endocrinology / European Feder

VOLUME: 155

Page Numbers: 867-75

Journal Abbreviation: Eur. J. Endocrinol.

ISSN: 0804-4643

DAY: 3

MONTH: Dec

YEAR: 2006

Effects of modest testosterone supplementation and exercise for 12 weeks on body composition and quality of life in elderly men. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9423848

Effects of modest testosterone supplementation and exercise for 12 weeks on body composition and quality of life in elderly men. Keywords Mesh Terms:

KEYWORDS: Treatment Outcome

MESH TERMS: blood

Chemical & Substance for Abstract: Effects of modest testosterone supplementation and exercise for 12 weeks on body composition and quality of life in elderly men. Information

Substance Name: Testosterone

Registry Number: 58-22-0

Grant and Affiliation Information for Effects of modest testosterone supplementation and exercise for 12 weeks on body composition and quality of life in elderly men.

AFFILIATION: Department of Medicine, Massachusetts General Hospital, Boston, MA 02114, USA. lkatznelson@stanford.edu

Country: England

AGENCY: United States NIA

GRANT: R29 AG15882-04

ACRONYM: AG

MEDLINETA: Eur J Endocrinol

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