[Effects of mitogens on the expression of interleukin-2 receptor and the cytotoxicity of human monocytes]

[Effects of mitogens on the expression of interleukin-2 receptor and the cytotoxicity of human monocytes] Research Abstract Details 

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[Effects of mitogens on the expression of interleukin-2 receptor and the cytotoxicity of human monocytes] Abstract Text:

J Chen,H Dong,

OBJECTIVE: To study the effects of mitogens on the expression of interleukin-2 receptor (IL-2R) and the cytotoxicity of human monocytes. METHODS: The effects of mitogens on the regulation of the expression of IL-2R alpha chain and the cytotoxicity of human monocytes were investigated. RESULTS: Pokeweed mitogen (PWM) and lipopolysaccharide (LPS) induced the expression of IL-2R alpha chain on human monocytes at 24h- and 48h-culture, phytohemagglutinin (PHA) did the same only at 48h-culture, while concanavalin (ConA) did not. After pretreatment with these mitogens, the addition of IL-2 enhanced cytotoxicity of monocytes only in those with IL-2R expression. The highest IL-2 induced cytotoxicity of monocytes was found in those pretreated with PWM. Flow cytometry showed that PWM bound to the surfaces of both monocytes and U937 target cells. The addition of IL-2 induced apoptosis of PWM-pretreated U937 cells. CONCLUSION: IL-2 enhanced monocyte-mediated cytotoxicity and target cell apoptosis, which could be augmented by mitogen induced IL-2R expression on monocytes.

[Effects of mitogens on the expression of interleukin-2 receptor and the cytotoxicity of human monocytes] Publishing Authors By Initials

J Chen,H Dong,

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[Effects of mitogens on the expression of interleukin-2 receptor and the cytotoxicity of human monocytes] Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Zhonghua xue ye xue za zhi = Zhonghua xueyexue zaz

VOLUME: 18

Page Numbers: 291-4

Journal Abbreviation: Zhonghua Xue Ye Xue Za Zhi

ISSN: 0253-2727

DAY: 29

MONTH: Jun

YEAR: 1997

[Effects of mitogens on the expression of interleukin-2 receptor and the cytotoxicity of human monocytes] Information

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LANGUAGE: chi

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Grant and Affiliation Information for [Effects of mitogens on the expression of interleukin-2 receptor and the cytotoxicity of human monocytes]

AFFILIATION: Department of Rheumatology, Second Affiliated Hospital, Dalian Medical University, Dalian 116023.

Country: China

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MEDLINETA: Zhonghua Xue Ye Xue Za Zhi

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