Effects of lycopene on the induction of foam cell formation by modified LDL.

Effects of lycopene on the induction of foam cell formation by modified LDL. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Effects of lycopene on the induction of foam cell formation by modified LDL. Abstract Text:

Mariarosaria Napolitano,Clara De Pascale,Caroline Wheeler-Jones,Kathleen M Botham,Elena Bravo,Mariarosaria Napolitano,Clara De Pascale,Caroline Wheeler-Jones,Kathleen M Botham,Elena Bravo,

The effect of lycopene on macrophage foam cell formation induced by modified low-density lipoprotein (LDL) was studied. Human monocyte-derived macrophages (HMDM) were incubated with lycopene in the presence or absence of native LDL (nLDL) or LDL modified by oxidation (oxLDL), aggregation (aggLDL), or acetylation (acLDL). The cholesterol content, lipid synthesis, scavenger receptor activity, and the secretion of inflammatory [interleukin (IL)-1beta and tumor necrosis factor (TNF)-alpha] and anti-inflammatory (IL-10) cytokines was determined. Lycopene was found to decrease the synthesis of cholesterol ester in incubations without LDL or with oxLDL while triacylglycerol synthesis was reduced in the presence of oxLDL and aggLDL. Scavenger receptor activity as assessed by the uptake of acLDL was decreased by approximately 30% by lycopene. In addition, lycopene inhibited IL-10 secretion by up to 74% regardless of the presence of nLDL or aggLDL but did not affect IL-1beta or TNF-alpha release. Lycopene also reduced the relative abundance of mRNA transcripts for scavenger receptor A (SR-A) in THP-1 macrophages treated with aggLDL. These findings suggest that lycopene may reduce macrophage foam cell formation induced by modified LDL by decreasing lipid synthesis and downregulating the activity and expression of SR-A. However, these effects are accompanied by impaired secretion of the anti-inflammatory cytokine IL-10, suggesting that lycopene may also exert a concomitant proinflammatory effect.

Effects of lycopene on the induction of foam cell formation by modified LDL. Publishing Authors By Initials

M Napolitano,C De Pascale,C Wheeler-Jones,KM Botham,E Bravo,M Napolitano,C De Pascale,C Wheeler-Jones,KM Botham,E Bravo,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Effects of lycopene on the induction of foam cell formation by modified LDL. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: American journal of physiology. Endocrinology and

VOLUME: 293

Page Numbers: E1820-7

Journal Abbreviation: Am. J. Physiol. Endocrinol. Me

ISSN: 0193-1849

DAY: 2

MONTH: 10

YEAR: 2007

Effects of lycopene on the induction of foam cell formation by modified LDL. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 100901226

Effects of lycopene on the induction of foam cell formation by modified LDL. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Effects of lycopene on the induction of foam cell formation by modified LDL. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Effects of lycopene on the induction of foam cell formation by modified LDL.

AFFILIATION: Istituto Superiore di Sanitá, Dept. of Haematology, Oncology and Molecular Medicine, Viale Regina Elena 299, 00161 Rome, Italy. bravo@iss.it).

Country: United States

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Am J Physiol Endocrinol Metab

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Effects of lycopene on the induction of foam cell formation by modified LDL Related Publications

• A Bacillus thuringiensis S-layer protein involved in toxicity against Epilachna varivestis (Coleoptera: Coccinellidae).
• Bacillus thuringiensis ssp. israelensis Cyt1Aa enhances activity of Cry11Aa toxin by facilitating the formation of a pre-pore oligomeric structure.
• Characterisation of carbapenem-resistant Acinetobacter calcoaceticus-A. baumannii complex isolates in a third-level hospital in Bogotá, Colombia.
• Effects of lycopene on the induction of foam cell formation by modified LDL.
• Emerging diseases in tropical dermatology.
• Engineering modified Bt toxins to counter insect resistance.
• Ferrier sulfonamidoglycosylation of D-glycals.
• First record and description of a new species of Sycorax Curtis (Diptera: Psychodidae, Sycoracinae) from the Brazilian Amazon.
• Hypolipidaemic activity of aqueous Ocimum basilicum extract in acute hyperlipidaemia induced by triton WR-1339 in rats and its antioxidant property.
• Identifying characteristics of residential care facilities relevant to the placement process of seniors.
• Induction of ion transport in rat heart mitochondria by fluorescamine.
• Insulin-like growth factor system gene expression in cervical scrapes from women with squamous intraepithelial lesions and cervical cancer.
• Job stress and burnout in residential child care workers in Spain.
• Mode of action of mosquitocidal Bacillus thuringiensis toxins.
• Prevalence and victimization correlates of pathological dissociation in a community sample of youths.
• Proteomics-based strategy to delineate the molecular mechanisms of the metastasis suppressor gene BRMS1.
• Role of receptor interaction in the mode of action of insecticidal Cry and Cyt toxins produced by Bacillus thuringiensis.
• Structural and functional analysis of the pre-pore and membrane-inserted pore of Cry1Ab toxin.
• The first hydrophobic region of the HPV16 E5 protein determines protein cellular location and facilitates anchorage-independent growth.
• The pre-pore from Bacillus thuringiensis Cry1Ab toxin is necessary to induce insect death in Manduca sexta.
• The use of a flowable ormocer for bonding brackets.
• Using fluorescent aromatic compounds in bile from juvenile salmonids to predict exposure to polycyclic aromatic hydrocarbons.
• [Demography and development]
• [Fetal distress. Obstetrical consequence and consequence in the newborn.]
• [Not Available.]
• [Not Available.]
• [Regionalization: organization and coordinated functioning of the health services in rural and urban zones]
• [Studies on the most frequent mycoses in tropical areas.]
• [The modern hospital as a health service]
• [Vago's technic of staining of spirochetes.]