Effects of LPA and S1P on the nervous system and implications for their involvement in disease.

Effects of LPA and S1P on the nervous system and implications for their involvement in disease. Research Abstract Details 

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Effects of LPA and S1P on the nervous system and implications for their involvement in disease. Abstract Text:

D R Herr,J Chun,

Lysophosphatidic acid (LPA) and sphingosine 1-phosphate (S1P) are two well-studied lysophospholipids that are known to be important regulators of cellular events. Their actions are mediated by activating a family of G-protein coupled receptors present in many cell types and tissues. These receptors have diverse biological roles owing to the heterogeneity of their signal transduction pathways. Many of these receptors are expressed in subsets of cells in the developing and mature mammalian nervous system and are thought to have important functions in its formation and maintenance. They are also widely expressed within other organ systems such as the immune system. Growing interest in the field has stimulated the development of a number of molecules that act as agonists or antagonists to LPA and S1P receptors. These molecules may lead to the development of new therapeutic compounds. Indeed, one such compound (FTY720) is currently in clinical trials for use in preventing transplant rejection and treating multiple sclerosis. The purpose of this manuscript is to: 1) review effects elicited by LPA and S1P on cells and tissues with a particular emphasis on the nervous system, 2) examine possible roles of these lipids in the development of disease, and 3) summarize the existing literature describing their agonists/antagonists.

Effects of LPA and S1P on the nervous system and implications for their involvement in disease. Publishing Authors By Initials

DR Herr,J Chun,

For similar organic chemicals: alcohols: amino alcohols: sphingosine research abstracts see: organic chemicals: alcohols: amino alcohols: sphingosine research

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Effects of LPA and S1P on the nervous system and implications for their involvement in disease. Journal Published:

PUBLICATION TYPE: Review

Journal: Current drug targets

VOLUME: 8

Page Numbers: 155-67

Journal Abbreviation:

ISSN: 1873-5592

DAY: 3

MONTH: Jan

YEAR: 2007

Effects of LPA and S1P on the nervous system and implications for their involvement in disease. Information

Number of References: 161

LANGUAGE: eng

NlmUniqueID: 100960531

Effects of LPA and S1P on the nervous system and implications for their involvement in disease. Keywords Mesh Terms:

KEYWORDS: Sphingosine

MESH TERMS: physiology

Chemical & Substance for Abstract: Effects of LPA and S1P on the nervous system and implications for their involvement in disease. Information

Substance Name: sphingosine 1-phosphate

Registry Number: 26993-30-6

Grant and Affiliation Information for Effects of LPA and S1P on the nervous system and implications for their involvement in disease.

AFFILIATION: Department of Molecular Biology, Helen L. Dorris Child and Adolescent Neuropsychiatric Disorder Institute, The Scripps Research Institute, 10550 N. Torrey Pines Road, La Jolla, California 92037, USA.

Country: Netherlands

AGENCY: United States NINDS

GRANT: R01 NS048478

ACRONYM: NS

MEDLINETA: Curr Drug Targets

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