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[Effects of Low-G preconditioning on contractive ability of left ventricle and contents of endothelin and prostacycline in myocardium of rats after repeated +10 Gz stress]

[Effects of Low-G preconditioning on contractive ability of left ventricle and contents of endothelin and prostacycline in myocardium of rats after repeated +10 Gz stress] Research Abstract Details 

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  • [Effects of Low-G preconditioning on contractive ability of left ventricle and contents of endothelin and prostacycline in myocardium of rats after repeated +10 Gz stress] Abstract Text:

    feng-ying fuFeng-Ying Fu,hao zhanHao Zhan,zheng zhangZheng Zhang,tong liTong Li,yi-mei xinYi-Mei Xin,si-huang weiSi-Huang Wei,

    Objective: To further test the protective effect of low-G pre-conditioning on + Gz stress induced cardiac damage. Method: Forty-two male Wistar rats were randomly divided into 3 groups (n = 14 for each group): group A (+1 Gz group), group B (+10 Gz group) and group C (low-G pre-conditioning group). The rats in group B were exposed to five +10 Gz plateaus of 30 s with 1 min intervals at + 1 Gz, 3 times a week, for 3 weeks; while group A were only submitted to +1 Gz for 5 min. The rats in group C were exposed to +2 Gz for 5 min about 1 h prior to +10 Gz stress. All the animals were decapitated in the next day after the last centrifuge run and function of the isolated working hearts and contents of endothelin and prostacycline in the myocardium were observed. Result: Compared with the control, a significant decrease of left ventricular systolic pressure (LVSP) and increase of myocardial contents of endothelin in rats were observed after repeated +10 Gz exposure; but low-G pre-conditioning could remarkably elevate the LVSP and reduce the myocardial endothelin level in rats after repeated +10 Gz stress. Conclusion: Low-G pre-conditioning has a significant protective effect on contractive ability of the left ventricle and secretion function of the vascular endothelium in rat heart after high G stress.

    [Effects of Low-G preconditioning on contractive ability of left ventricle and contents of endothelin and prostacycline in myocardium of rats after repeated +10 Gz stress] Publishing Authors By Initials

    fy fuFY Fu,h zhanH Zhan,z zhangZ Zhang,t liT Li,ym xinYM Xin,sh weiSH Wei,

    For similar abstracts research abstracts see: abstracts research

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    [Effects of Low-G preconditioning on contractive ability of left ventricle and contents of endothelin and prostacycline in myocardium of rats after repeated +10 Gz stress] Journal Published:

    PUBLICATION TYPE: Journal Article

    Journal: Hang tian yi xue yu yi xue gong cheng = Space medi

    VOLUME: 16

    Page Numbers: 414-7

    Journal Abbreviation:

    ISSN: 1002-0837

    DAY: 9

    MONTH: Dec

    YEAR: 2003

    [Effects of Low-G preconditioning on contractive ability of left ventricle and contents of endothelin and prostacycline in myocardium of rats after repeated +10 Gz stress] Information

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    LANGUAGE: chi

    NlmUniqueID: 9425305

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    Grant and Affiliation Information for [Effects of Low-G preconditioning on contractive ability of left ventricle and contents of endothelin and prostacycline in myocardium of rats after repeated +10 Gz stress]

    AFFILIATION: Medical Division, Peking University, Beijing, China.

    Country: China

    China Research PublicationChina Research Publication

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    MEDLINETA: Space Med Med Eng (Beijing)

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