Effects of low concentration of dihydroouabain on intracellular calcium in guinea pig ventricular myocytes.

Effects of low concentration of dihydroouabain on intracellular calcium in guinea pig ventricular myocytes. Research Abstract Details 

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Effects of low concentration of dihydroouabain on intracellular calcium in guinea pig ventricular myocytes. Abstract Text:

Jing-Xiang Yin,Yong-Li Wang,Qing Li,Zhong-Lin Shang,Su-Wen Su,

The effects of low concentration of dihydroouabain (DHO) on intracellular calcium concentration ([Ca(2+)](i)) were investigated in guinea pig ventricular myocytes. [Ca(2+)](i) was detected by confocal microscopy and represented by fluorescent intensity. DHO (1 fmol/L~1 mmol/L) increased [Ca(2+)](i), especially at 10 pmol/L. Nisoldipine, egtazic acid, or tetrodotoxin partially inhibited the effect of 10 pmol/L DHO on [Ca(2+)](i). The effects of DHO remained in the absence of extracellular K(+) and Na(+). These results suggest that low concentration of DHO might increase [Ca(2+)](i) via the receptor-operated Ca(2+) channels, TTX-sensitive Na(+) channels or/and triggering of intracellular calcium release; Na(+)/K(+) pump and Na(+)/Ca(2+) exchange seem not involved in the effect of DHO.

Effects of low concentration of dihydroouabain on intracellular calcium in guinea pig ventricular myocytes. Publishing Authors By Initials

JX Yin,YL Wang,Q Li,ZL Shang,SW Su,

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Effects of low concentration of dihydroouabain on intracellular calcium in guinea pig ventricular myocytes. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Sheng li xue bao : [Acta physiologica Sinica]

VOLUME: 54

Page Numbers: 385-9

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ISSN: 0371-0874

DAY: 25

MONTH: Oct

YEAR: 2002

Effects of low concentration of dihydroouabain on intracellular calcium in guinea pig ventricular myocytes. Information

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LANGUAGE: eng

NlmUniqueID: 20730130

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Grant and Affiliation Information for Effects of low concentration of dihydroouabain on intracellular calcium in guinea pig ventricular myocytes.

AFFILIATION: Department of Pharmacology, Institute of Basic Medicine, Hebei Medical University, Shijiazhuang, China.

Country: China

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MEDLINETA: Sheng Li Xue Bao

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