Effects of lipid chain lengths in alpha-galactosylceramides on cytokine release by natural killer T cells.

Effects of lipid chain lengths in alpha-galactosylceramides on cytokine release by natural killer T cells. Research Abstract Details 

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Effects of lipid chain lengths in alpha-galactosylceramides on cytokine release by natural killer T cells. Abstract Text:

Randal D Goff,Ying Gao,Jochen Mattner,Dapeng Zhou,Ning Yin,Carlos Cantu,Luc Teyton,Albert Bendelac,Paul B Savage,

Glycolipid presentation by CD1 proteins has emerged as an important aspect of antigen recognition, and presentation of alpha-glycosylceramides by CD1d to natural killer T cells has become a central focus in understanding how glycolipid presentation can influence immune responses. An alpha-galactosylceramide containing relatively long lipid chains has been the subject of intense study because, when presented by CD1d to natural killer T cells, it stimulates the release of both proinflammatory and immunomodulatory cytokines. Using an efficient synthesis of alpha-galactosylceramides, we have prepared a series of glycolipids in which the lipid chain lengths have been incrementally varied. The responses of natural killer T cells to these glycolipids have been determined, and we have found that truncation of the phytosphingosine lipid chain increases the relative amounts of immunomodulatory cytokines released. In similar fashion, the length of the acyl chain in alpha-galactosylceramides influences cytokine release profiles.

Effects of lipid chain lengths in alpha-galactosylceramides on cytokine release by natural killer T cells. Publishing Authors By Initials

RD Goff,Y Gao,J Mattner,D Zhou,N Yin,C Cantu,L Teyton,A Bendelac,PB Savage,

For similar cells: blood cells: leukocytes: leukocytes, mononuclear: lymphocytes: t-lymphocytes research abstracts see: cells: blood cells: leukocytes: leukocytes, mononuclear: lymphocytes: t-lymphocytes research

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Effects of lipid chain lengths in alpha-galactosylceramides on cytokine release by natural killer T cells. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Journal of the American Chemical Society

VOLUME: 126

Page Numbers: 13602-3

Journal Abbreviation: J. Am. Chem. Soc.

ISSN: 0002-7863

DAY: 27

MONTH: Oct

YEAR: 2004

Effects of lipid chain lengths in alpha-galactosylceramides on cytokine release by natural killer T cells. Information

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LANGUAGE: eng

NlmUniqueID: 7503056

Effects of lipid chain lengths in alpha-galactosylceramides on cytokine release by natural killer T cells. Keywords Mesh Terms:

KEYWORDS: T-Lymphocytes

MESH TERMS: secretion

Chemical & Substance for Abstract: Effects of lipid chain lengths in alpha-galactosylceramides on cytokine release by natural killer T cells. Information

Substance Name: Galactosylceramides

Registry Number: 0

Grant and Affiliation Information for Effects of lipid chain lengths in alpha-galactosylceramides on cytokine release by natural killer T cells.

AFFILIATION: Brigham Young University, Provo, Utah 84602, USA.

Country: United States

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MEDLINETA: J Am Chem Soc

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