Effects of leukemia inhibitory factor on lectin-binding patterns in the uterine stromal vessels of mice.

Effects of leukemia inhibitory factor on lectin-binding patterns in the uterine stromal vessels of mice. Research Abstract Details 

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Effects of leukemia inhibitory factor on lectin-binding patterns in the uterine stromal vessels of mice. Abstract Text:

Shoichi Wakitani,Eiichi Hondo,Tetsuya Shimokawa,Ken Kusakabe,Toshiya Okada,Nobuaki Nakamuta,Colin L Stewart,Yasuo Kiso,Shoichi Wakitani,Eiichi Hondo,Tetsuya Shimokawa,Ken Kusakabe,Toshiya Okada,Nobuaki Nakamuta,Colin L Stewart,Yasuo Kiso,

Lectin histochemistry was performed on mouse uteri to determine what effects leukemia inhibitory factor (LIF) has on carbohydrate epitope expressions at the time of implantation. Twenty-two biotinylated lectins were used in this study. Following injection of LIF, specific binding to the apical surface of the uterine glandular epithelium (GE) was recognized by six lectins. Particularly, binding of the lectin from Griffonia (Bandeiraea) simplicifolia was specific to the glandular epithelium close to the luminal epithelium. Succinylated wheat germ agglutinin (WGA), which has specificity for oligosaccharides recognized by WGA without sialic acid residues, showed weaker binding to the uterine luminal epithelium (LE) and the stroma than WGA, suggesting that terminal residues of glyco-conjugates on these tissues may be modified by sialic acids. Lectin binding to the glandular and luminal epithelium was not influenced by LIF. However, three lectins including a lectin from Dolichos biflorus showed specificity for stromal vessels 6h after LIF injection. Since the lectin from D. biflorus binds to neo-vascular vessels, LIF may play a role in regulating maternal angiogenesis directly and/or indirectly during implantation.

Effects of leukemia inhibitory factor on lectin-binding patterns in the uterine stromal vessels of mice. Publishing Authors By Initials

S Wakitani,E Hondo,T Shimokawa,K Kusakabe,T Okada,N Nakamuta,CL Stewart,Y Kiso,S Wakitani,E Hondo,T Shimokawa,K Kusakabe,T Okada,N Nakamuta,CL Stewart,Y Kiso,

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Effects of leukemia inhibitory factor on lectin-binding patterns in the uterine stromal vessels of mice. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Immunobiology

VOLUME: 213

Page Numbers: 143-50

Journal Abbreviation: Immunobiology

ISSN: 0171-2985

DAY: 22

MONTH: 10

YEAR: 2007

Effects of leukemia inhibitory factor on lectin-binding patterns in the uterine stromal vessels of mice. Information

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LANGUAGE: eng

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Grant and Affiliation Information for Effects of leukemia inhibitory factor on lectin-binding patterns in the uterine stromal vessels of mice.

AFFILIATION: Department of Veterinary Anatomy, Faculty of Agriculture, Yamaguchi University, 1677-1 Yoshida, Yamaguchi 753-8511, Japan.

Country: Germany

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MEDLINETA: Immunobiology

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