[Effects of lead exposure to rat placenta and pups during different gestation periods]

[Effects of lead exposure to rat placenta and pups during different gestation periods] Research Abstract Details 

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[Effects of lead exposure to rat placenta and pups during different gestation periods] Abstract Text:

Hai-yan Ma,Hong Li,Jiao-chen Wang,Xiu-qin Liu,Feng-sen Xu,Jin-shan Tan,

OBJECTIVE: To investigate the effects of lead exposure to rat placenta and pups during different gestation periods. METHODS: All 108 Wistar rats (72 females, 36 males) were randomly divided into four groups. All rats were orally fed with 0.025% lead acetate during different gestation periods. Blood was obtained from the abdominal vena cava and the lead level in maternal blood was measured by means of atomic absorption spectrometry at the end of the pregnancy. The number of pups, their body weight, body length and tail length were measured. The effects of lead to rat placenta were observed by level of microscopy, optical microscopy and electronic microscopy. RESULTS: Experimental groups the blood lead level at the end of gestation were above 0.483 micromol/L. There were significant differences among, of pups, during different groups (P < 0.01). Among them the drinking lead group of whole distans was the lowest in placenta weight [(0.31 +/- 0.13) g] body weight of pups [(2.08 +/- 0.88) g] length and tail length of pups [(2.37 +/- 0.32) cm, (0.98 +/- 0.09) cm]. There were significantly differences between the experimental groups and controls. Maternal blood lead level was negatively related to placenta weight (r = 0.652, P < 0.01), and had no relation with the body weight of pups (r = -0.107, P = 0.46). In the experimental groups of lead poisoned rats, the placenta showed focus necrosis in the deciduas, and increased the trophoblastic giant cells and light staining cells in the trophospongium. Trophoblast in the labyrinth and trophospongium showed degeneration; fibrin deposition around the villi was increased. Microvilli around the trophoblast were shorter and less, mitochondrion was swollen and decreased in number, rough endoplasmic reticulum was distended and ribosomal number on membrane decreased. CONCLUSION: Lead exposure during different gestation periods should have a traumatic effect on the trophoblast, leading to interference of nutrition and oxygen exchange. Furthermore, the blood supply to the placenta and nutrition and oxygen exchange between mother and pups were also interfered, leading to reduction of placenta weight and retardation of development of pups.

[Effects of lead exposure to rat placenta and pups during different gestation periods] Publishing Authors By Initials

HY Ma,H Li,JC Wang,XQ Liu,FS Xu,JS Tan,

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[Effects of lead exposure to rat placenta and pups during different gestation periods] Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Zhonghua yu fang yi xue za zhi [Chinese journal of

VOLUME: 40

Page Numbers: 101-4

Journal Abbreviation: Zhonghua Yu Fang Yi Xue Za Zhi

ISSN: 0253-9624

DAY: 27

MONTH: Mar

YEAR: 2006

[Effects of lead exposure to rat placenta and pups during different gestation periods] Information

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LANGUAGE: chi

NlmUniqueID: 7904962

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Grant and Affiliation Information for [Effects of lead exposure to rat placenta and pups during different gestation periods]

AFFILIATION: Department of Paediatrics, Department of Pathology, Qingdao Municipal Hospital, Qingdao 266011, China.

Country: China

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MEDLINETA: Zhonghua Yu Fang Yi Xue Za Zhi

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