Effects of lamivudine on outcome after liver resection for hepatocellular carcinoma in patients with active replication of hepatitis B virus.

Effects of lamivudine on outcome after liver resection for hepatocellular carcinoma in patients with active replication of hepatitis B virus. Research Abstract Details 

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Effects of lamivudine on outcome after liver resection for hepatocellular carcinoma in patients with active replication of hepatitis B virus. Abstract Text:

Shoji Kubo,Hiromu Tanaka,Shigekazu Takemura,Satoshi Yamamoto,Seikan Hai,Tsuyoshi Ichikawa,Shintaro Kodai,Hiroji Shinkawa,Hiroki Sakaguchi,Akihiro Tamori,Daiki Habu,Shuhei Nishiguchi,

Aim: Patients with high serum hepatitis B virus (HBV) DNA concentrations are at high risk of tumor recurrence after liver resection for HBV-related hepatocellular carcinoma (HCC). Methods: Among 24 patients with high serum HBV DNA concentrations who underwent liver resection for HBV-related HCC, postoperative lamivudine therapy was chosen by 14 (lamivudine group). The other 10 patients were controls. Results: Clinicopathologic findings did not differ between the groups. Tumor-free survival rate after surgery was significantly higher in the lamivudine than the control group (P = 0.0086). By univariate analysis, multiple tumors were also a risk factor for a short tumor-free survival. By multivariate analysis, lack of lamivudine therapy and multiple tumors were independent risk factors for a short tumor-free survival. In four patients YMDD mutant viruses were detected after beginning lamivudine administration; in two of them, adefovir dipivoxil was administered because of sustained serum alanine aminotransferase elevations. Conclusion: Lamivudine therapy improved tumor-free survival rate after curative resection of HBV-related HCC in patients with high serum concentrations of HBV DNA, although careful follow up proved necessary for the detection of YMDD mutant viruses.

Effects of lamivudine on outcome after liver resection for hepatocellular carcinoma in patients with active replication of hepatitis B virus. Publishing Authors By Initials

S Kubo,H Tanaka,S Takemura,S Yamamoto,S Hai,T Ichikawa,S Kodai,H Shinkawa,H Sakaguchi,A Tamori,D Habu,S Nishiguchi,

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Effects of lamivudine on outcome after liver resection for hepatocellular carcinoma in patients with active replication of hepatitis B virus. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Hepatology research : the official journal of the

VOLUME: 37

Page Numbers: 94-100

Journal Abbreviation: Hepatol. Res.

ISSN: 1386-6346

DAY: 15

MONTH: Feb

YEAR: 2007

Effects of lamivudine on outcome after liver resection for hepatocellular carcinoma in patients with active replication of hepatitis B virus. Information

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LANGUAGE: eng

NlmUniqueID: 9711801

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AFFILIATION: Departments of Hepato-Biliary-Pancreatic Surgery, Osaka City University Graduate School of Medicine, Osaka, Japan.

Country: Netherlands

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MEDLINETA: Hepatol Res

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