Effects of L-arginine and L-NAME on chronic partial bladder outlet obstruction in rabbit.

Effects of L-arginine and L-NAME on chronic partial bladder outlet obstruction in rabbit. Research Abstract Details 

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Effects of L-arginine and L-NAME on chronic partial bladder outlet obstruction in rabbit. Abstract Text:

Wei-Yu Lin,Robert M Levin,Paul Chichester,Robert Leggett,Yung-Shun Juan,Arnold Johnson,Paul Neumann,Catherine Whitbeck,Ahmet Guven,Barry Kogan,Anita Mannikarottu,Wei-Yu Lin,Robert M Levin,Paul Chichester,Robert Leggett,Yung-Shun Juan,Arnold Johnson,Paul Neumann,Catherine Whitbeck,Ahmet Guven,Barry Kogan,Anita Mannikarottu,Wei-Yu Lin,Robert M Levin,Paul Chichester,Robert Leggett,Yung-Shun Juan,Arnold Johnson,Paul Neumann,Catherine Whitbeck,Ahmet Guven,Barry Kogan,Anita Mannikarottu,

Nitric oxide (NO) is synthesized from L-arginine by nitric oxide synthase (NOS). NOS can be inhibited by NG-nitro-L-arginine methyl ester (L-NAME) and stimulated by supplementing the diet with L-arginine. The aim of this study was to investigate the influence of NOS activity on the response of rabbits to chronic partial bladder outlet obstruction (PBOO). Surgical PBOOs (2 and 8 wk) were performed on male New Zealand White rabbits. Before obstruction, one-third of the animals were premedicated for 7 days with L-NAME and another third with L-arginine. The results are summarized as follows. First, bladder weight after 8-wk PBOO was significantly lower in animals treated with L-arginine compared with both untreated and rabbits treated with L-NAME. Second, contractile function decreased progressively with PBOO duration. However, after 8 wk of PBOO, the L-arginine group had significantly greater contractile function compared with the no-treatment group, and the L-NAME group had significantly lower contractile function compared with the no-treatment group. Third, at 8 wk following PBOO, the level of protein oxidation and nitration was lowest for the L-arginine group and highest in the L-NAME group. These studies clearly demonstrated that increasing blood flow by stimulating NOS significantly protected the bladder from PBOO dysfunctions, whereas inhibiting blood flow by L-NAME enhanced the dysfunctions mediated by PBOO.

Effects of L-arginine and L-NAME on chronic partial bladder outlet obstruction in rabbit. Publishing Authors By Initials

WY Lin,RM Levin,P Chichester,R Leggett,YS Juan,A Johnson,P Neumann,C Whitbeck,A Guven,B Kogan,A Mannikarottu,WY Lin,RM Levin,P Chichester,R Leggett,YS Juan,A Johnson,P Neumann,C Whitbeck,A Guven,B Kogan,A Mannikarottu,WY Lin,RM Levin,P Chichester,R Leggett,YS Juan,A Johnson,P Neumann,C Whitbeck,A Guven,B Kogan,A Mannikarottu,

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Effects of L-arginine and L-NAME on chronic partial bladder outlet obstruction in rabbit. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: American journal of physiology. Regulatory, integr

VOLUME: 293

Page Numbers: R2390-9

Journal Abbreviation: Am. J. Physiol. Regul. Integr.

ISSN: 0363-6119

DAY: 10

MONTH: 10

YEAR: 2007

Effects of L-arginine and L-NAME on chronic partial bladder outlet obstruction in rabbit. Information

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LANGUAGE: eng

NlmUniqueID: 100901230

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Grant and Affiliation Information for Effects of L-arginine and L-NAME on chronic partial bladder outlet obstruction in rabbit.

AFFILIATION: Division of Urology, Chang Gung Memorial Hospital, Chia-Yi, Taiwan.

Country: United States

AGENCY: United States NIDDK

GRANT: R0-1-DK-067114

ACRONYM: DK

MEDLINETA: Am J Physiol Regul Integr Comp

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