Effects of kainic and other amino acids on synaptic excitation in rat hippocampal slices: 1. Extracellular analysis.

Effects of kainic and other amino acids on synaptic excitation in rat hippocampal slices: 1. Extracellular analysis. Research Abstract Details 

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Effects of kainic and other amino acids on synaptic excitation in rat hippocampal slices: 1. Extracellular analysis. Abstract Text:

G L Collingridge,S J Kehl,R Loo,H McLennan,

The actions of kainic acid on excitatory synaptic responses in rat hippocampal slices have been investigated and compared with the effects of other excitatory amino acids. Kainate administered iontophoretically or via the superfusate produced a large and long lasting potentiation of the population spike evoked in the CA1 region by Schaffer collateral-commissural stimulation. This potentiation was associated with a reduction in the field EPSP recorded in the dendritic region (stratum radiatum) but with no change in the presynaptic fibre volley or with any long lasting alteration in the antidromic population spike. The results suggest that one effect of kainate may be to produce dendritic depolarisation in CA1 pyramidal neurones. Kainate in equivalent amounts elicited similar potentiations of the population spike recorded in the dentate gyrus in response to either lateral or medial perforant path stimulation. Smaller amounts of kainate than those required to affect either CA1 or dentate pathways were able to potentiate the mossy fibre-evoked population spike in the CA3 region. Folic acid, which shares kainate's ability to produce seizures and distant brain damage when injected into the brain, elicited similar potentiations of synaptic excitation. Higher doses of folate than of kainate were required which is consistent with its weaker epileptogenic actions in vivo. In contrast, N-methyl-aspartate, ibotenate, L-glutamate and L-aspartate were unable to mimic kainate's potentiating action. In higher doses the substances depressed the population spike for long periods. These data suggest that potentiation of synaptic events may underlie the ability of kainate (and folate) to elicit seizures and distant brain damage.

Effects of kainic and other amino acids on synaptic excitation in rat hippocampal slices: 1. Extracellular analysis. Publishing Authors By Initials

GL Collingridge,SJ Kehl,R Loo,H McLennan,

For similar animals: chordata: vertebrates: mammals: rodentia: muridae: murinae: rats research abstracts see: animals: chordata: vertebrates: mammals: rodentia: muridae: murinae: rats research

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Effects of kainic and other amino acids on synaptic excitation in rat hippocampal slices: 1. Extracellular analysis. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Experimental brain research. Experimentelle Hirnfo

VOLUME: 52

Page Numbers: 170-8

Journal Abbreviation:

ISSN: 0014-4819

DAY: 15

MONTH: 02

YEAR: 1983

Effects of kainic and other amino acids on synaptic excitation in rat hippocampal slices: 1. Extracellular analysis. Information

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LANGUAGE: eng

NlmUniqueID: 43312

Effects of kainic and other amino acids on synaptic excitation in rat hippocampal slices: 1. Extracellular analysis. Keywords Mesh Terms:

KEYWORDS: Rats

MESH TERMS: pharmacology

Chemical & Substance for Abstract: Effects of kainic and other amino acids on synaptic excitation in rat hippocampal slices: 1. Extracellular analysis. Information

Substance Name: Aspartate Aminotransferases

Registry Number: EC 2.6.1.1

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Country: GERMANY, WEST

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MEDLINETA: Exp Brain Res

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