Effects of intrafractional motion on water equivalent pathlength in respiratory-gated heavy charged particle beam radiotherapy.

Effects of intrafractional motion on water equivalent pathlength in respiratory-gated heavy charged particle beam radiotherapy. Research Abstract Details 

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Effects of intrafractional motion on water equivalent pathlength in respiratory-gated heavy charged particle beam radiotherapy. Abstract Text:

Shinichiro Mori,George T Y Chen,Masahiro Endo,

PURPOSE: To analyze the water equivalent pathlength (WEL) fluctuations resulting from cardiac motion and display these variations on a beam's-eye-view image; the analysis provides insight into the accuracy of lung tumor irradiation with heavy charged particle beams. MATERIALS AND METHODS: Volumetric cine computed tomography (CT) images were obtained on 7 lung cancer patients under free-breathing conditions with a 256-multislice CT scanner. Cardiac phase was determined by selecting systole and diastole. A WEL difference image (DeltaWEL) was calculated by subtracting the WEL image at end-systole from that at end-diastole at respiratory exhalation phase. Two calculation regions were defined: Region 1 was limited to the volume defined by planes bounding the heart; Region 2 included the entire body thickness for a given beam's-eye-view angle. RESULTS: The DeltaWEL values observed in Region 1 showed fluctuations at the periphery of the heart that varied from 20.4 (SD, 5.2) mm WEL to -15.6 (3.2) mm WEL. The areas over which these range perturbation values were observed were 36.8 (32.4) mm(2) and 6.0 (2.8) mm(2) for positive and negative WEL, respectively. The WEL fluctuations in Region 2 increased by approximately 3-4 mm WEL, whereas negative WEL fluctuations changed by approximately -4 to -5 mm WEL, compared with WEL for Region 1; areas over 20 mm WEL changes in Region 2 increased by 9 mm(2) for positive DeltaWEL and 2 mm(2) for negative DeltaWEL. CONCLUSIONS: Cine CT with a 256-multislice CT scanner captures both volumetric cardiac and respiratory motion with a temporal resolution sufficient to estimate range fluctuations by these motions. This information can be used to assess the range perturbations that charged particle beams may experience in irradiation of lung or esophageal tumors adjacent to the heart.

Effects of intrafractional motion on water equivalent pathlength in respiratory-gated heavy charged particle beam radiotherapy. Publishing Authors By Initials

S Mori,GT Chen,M Endo,

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Effects of intrafractional motion on water equivalent pathlength in respiratory-gated heavy charged particle beam radiotherapy. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: International journal of radiation oncology, biolo

VOLUME: 69

Page Numbers: 308-17

Journal Abbreviation: Int. J. Radiat. Oncol. Biol. P

ISSN: 0360-3016

DAY: 1

MONTH: Sep

YEAR: 2007

Effects of intrafractional motion on water equivalent pathlength in respiratory-gated heavy charged particle beam radiotherapy. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7603616

Effects of intrafractional motion on water equivalent pathlength in respiratory-gated heavy charged particle beam radiotherapy. Keywords Mesh Terms:

KEYWORDS: Water

MESH TERMS: methods

Chemical & Substance for Abstract: Effects of intrafractional motion on water equivalent pathlength in respiratory-gated heavy charged particle beam radiotherapy. Information

Substance Name: Water

Registry Number: 7732-18-5

Grant and Affiliation Information for Effects of intrafractional motion on water equivalent pathlength in respiratory-gated heavy charged particle beam radiotherapy.

AFFILIATION: Department of Radiation Oncology, Massachusetts General Hospital, and Harvard Medical School, Boston, MA, USA. shinshin@nirs.go.jp

Country: United States

AGENCY: United States NCI

GRANT: P01 CA19138

ACRONYM: CA

MEDLINETA: Int J Radiat Oncol Biol Phys

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