Effects of inner ear trauma on the risk of pneumococcal meningitis.

Effects of inner ear trauma on the risk of pneumococcal meningitis. Research Abstract Details 

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Effects of inner ear trauma on the risk of pneumococcal meningitis. Abstract Text:

Benjamin P C Wei,Robert K Shepherd,Roy M Robins-Browne,Graeme M Clark,Stephen J O'Leary,

OBJECTIVE: To examine the risk of pneumococcal meningitis in healthy rats that received a severe surgical trauma to the modiolus and osseous spiral lamina or the standard insertion technique for acute cochlear implantation. DESIGN: Interventional animal studies. SUBJECTS: Fifty-four otologically normal adult Hooded-Wistar rats. INTERVENTIONS: Fifty-four rats (18 of which received a cochleostomy alone; 18, a cochleostomy and acute cochlear implantation using standard surgical techniques; and 18, a cochleostomy followed by severe inner ear trauma) were infected 4 weeks after surgery with Streptococcus pneumoniae via 3 different routes (hematogenous, middle ear, and inner ear) to represent all potential routes of bacterial infection from the upper respiratory tract to the meninges in cochlear implant recipients with meningitis. RESULTS: Severe trauma to the osseous spiral lamina and modiolus increased the risk of pneumococcal meningitis when the bacteria were given via the middle or inner ear (Fisher exact test, P<.05). However, the risk of meningitis did not change when the bacteria were given via the hematogenous route. Acute electrode insertion did not alter the risk of subsequent pneumococcal meningitis for any route of infection. CONCLUSIONS: Severe inner ear surgical trauma to the osseous spiral lamina and modiolus can increase the risk of pneumococcal meningitis. Therefore, every effort should be made to ensure that cochlear implant design and insertion technique cause minimal trauma to the bony structures of the inner ear to reduce the risk of pneumococcal meningitis.

Effects of inner ear trauma on the risk of pneumococcal meningitis. Publishing Authors By Initials

BP Wei,RK Shepherd,RM Robins-Browne,GM Clark,SJ O'Leary,

For similar bacteria: gram-positive bacteria: gram-positive cocci: streptococcaceae: streptococcus: streptococcus pneumoniae research abstracts see: bacteria: gram-positive bacteria: gram-positive cocci: streptococcaceae: streptococcus: streptococcus pneumoniae research

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Effects of inner ear trauma on the risk of pneumococcal meningitis. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Archives of otolaryngology--head & neck surgery

VOLUME: 133

Page Numbers: 250-9

Journal Abbreviation: Arch. Otolaryngol. Head Neck S

ISSN: 0886-4470

DAY: 3

MONTH: Mar

YEAR: 2007

Effects of inner ear trauma on the risk of pneumococcal meningitis. Information

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LANGUAGE: eng

NlmUniqueID: 8603209

Effects of inner ear trauma on the risk of pneumococcal meningitis. Keywords Mesh Terms:

KEYWORDS: Streptococcus pneumoniae

MESH TERMS: etiology

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Grant and Affiliation Information for Effects of inner ear trauma on the risk of pneumococcal meningitis.

AFFILIATION: Bionic Ear Institute and Departments of Otolaryngology and Microbiology and Immunology, University of Melbourne, Melbourne, Australia. bwei@bioniocear.org

Country: United States

AGENCY: United States NIDCD

GRANT: N01-DC-3-1005

ACRONYM: DC

MEDLINETA: Arch Otolaryngol Head Neck Sur

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