Effects of increasing numbers of phagocytic inclusions on human retinal pigment epithelial cells in culture: a model for aging.

Effects of increasing numbers of phagocytic inclusions on human retinal pigment epithelial cells in culture: a model for aging. Research Abstract Details 

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Effects of increasing numbers of phagocytic inclusions on human retinal pigment epithelial cells in culture: a model for aging. Abstract Text:

Cultures of human retinal pigment epithelial cells have been challenged with a number of biological (lipofuscin, melanin, and rod outer segments) and non-biological (latex microspheres) particles at a variety of concentrations. The particles were chosen to include examples of both degradable and non-degradable systems. A range of morphological changes were observed by phase contrast microscopy, and these became more atypical with increasing concentration. At the highest concentration cells had ingested so many particles that many had died and others had ruptured. The time course of these changes indicated a relationship between cellular lytic activity and the capacity of the particle to degrade. The potential of this system as a model for studying senescence is discussed.

Effects of increasing numbers of phagocytic inclusions on human retinal pigment epithelial cells in culture: a model for aging. Publishing Authors By Initials

For similar biological factors: pigments, biological: retinal pigments research abstracts see: biological factors: pigments, biological: retinal pigments research

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Effects of increasing numbers of phagocytic inclusions on human retinal pigment epithelial cells in culture: a model for aging. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: The British journal of ophthalmology

VOLUME: 70

Page Numbers: 808-15

Journal Abbreviation: Br J Ophthalmol

ISSN: 0007-1161

DAY: 28

MONTH: Nov

YEAR: 1986

Effects of increasing numbers of phagocytic inclusions on human retinal pigment epithelial cells in culture: a model for aging. Information

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LANGUAGE: eng

NlmUniqueID: 421041

Effects of increasing numbers of phagocytic inclusions on human retinal pigment epithelial cells in culture: a model for aging. Keywords Mesh Terms:

KEYWORDS: Retinal Pigments

MESH TERMS: cytology

Chemical & Substance for Abstract: Effects of increasing numbers of phagocytic inclusions on human retinal pigment epithelial cells in culture: a model for aging. Information

Substance Name: Retinal Pigments

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Country: ENGLAND

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MEDLINETA: Br J Ophthalmol

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