Effects of IL-6 and soluble IL-6 receptor on the expression of cartilage matrix proteins in human chondrocytes.

Effects of IL-6 and soluble IL-6 receptor on the expression of cartilage matrix proteins in human chondrocytes. Research Abstract Details 

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Effects of IL-6 and soluble IL-6 receptor on the expression of cartilage matrix proteins in human chondrocytes. Abstract Text:

Aki Namba,Yukiko Aida,Naoto Suzuki,Yusuke Watanabe,Takayuki Kawato,Masafumi Motohashi,Masao Maeno,Hideo Matsumura,Mitsuhiko Matsumoto,Aki Namba,Yukiko Aida,Naoto Suzuki,Yusuke Watanabe,Takayuki Kawato,Masafumi Motohashi,Masao Maeno,Hideo Matsumura,Mitsuhiko Matsumoto,Aki Namba,Yukiko Aida,Naoto Suzuki,Yusuke Watanabe,Takayuki Kawato,Masafumi Motohashi,Masao Maeno,Hideo Matsumura,Mitsuhiko Matsumoto,

Elevated concentrations of interleukin (IL)-6 and soluble IL-6 receptor (sIL-6Ralpha) in synovial fluid have been implicated in joint cartilage destruction. We examined the effect of IL-6 and sIL-6Ralpha on cell growth, alkaline phosphatase (ALPase) activity, and the expression of Sox-9, type II collagen, aggrecan core, link protein, BMP-7, and BMP receptors in human chondrocytes. Cell proliferation increased slightly in the presence of both IL-6 and sIL-6Ralpha, whereas ALPase activity decreased markedly. The expression of Sox-9 and aggrecan core did not change in the presence or absence of IL-6 and sIL-6Ralpha, whereas the expression of type II collagen, link protein, BMP-7, and BMP receptors increased in the presence of both IL-6 and sIL-6Ralpha. These results suggest that IL-6 and sIL-6Ralpha suppress the differentiation of chondrocytes and induce the repair of arthrodial cartilage through an increase in the expression of cartilage matrix proteins, BMP-7, and BMP receptors in the cells.

Effects of IL-6 and soluble IL-6 receptor on the expression of cartilage matrix proteins in human chondrocytes. Publishing Authors By Initials

A Namba,Y Aida,N Suzuki,Y Watanabe,T Kawato,M Motohashi,M Maeno,H Matsumura,M Matsumoto,A Namba,Y Aida,N Suzuki,Y Watanabe,T Kawato,M Motohashi,M Maeno,H Matsumura,M Matsumoto,A Namba,Y Aida,N Suzuki,Y Watanabe,T Kawato,M Motohashi,M Maeno,H Matsumura,M Matsumoto,

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Effects of IL-6 and soluble IL-6 receptor on the expression of cartilage matrix proteins in human chondrocytes. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Connective tissue research

VOLUME: 48

Page Numbers: 263-70

Journal Abbreviation: Connect. Tissue Res.

ISSN: 0300-8207

DAY: 20

MONTH: 09

YEAR: 2007

Effects of IL-6 and soluble IL-6 receptor on the expression of cartilage matrix proteins in human chondrocytes. Information

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LANGUAGE: eng

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AFFILIATION: Department of Oral and Maxillofacial Surgery, Nihon University School of Dentistry, Tokyo, Japan.

Country: United States

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MEDLINETA: Connect Tissue Res

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