Effects of hypoglycemia on human brain activation measured with fMRI.

Effects of hypoglycemia on human brain activation measured with fMRI. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Effects of hypoglycemia on human brain activation measured with fMRI. Abstract Text:

Adam W Anderson,Rubina A Heptulla,Naomi Driesen,Daniel Flanagan,Philip A Goldberg,Timothy W Jones,Fran Rife,Hedy Sarofin,William Tamborlane,Robert Sherwin,John C Gore,

Functional magnetic resonance imaging (fMRI) was used to measure the effects of acute hypoglycemia caused by passive sensory stimulation on brain activation. Visual stimulation was used to generate blood-oxygen-level-dependent (BOLD) contrast, which was monitored during hyperinsulinemic hypoglycemic and euglycemic clamp studies. Hypoglycemia (50 +/- 1 mg glucose/dl) decreased the fMRI signal relative to euglycemia in 10 healthy human subjects: the fractional signal change was reduced by 28 +/- 12% (P < .05). These changes were reversed when euglycemia was restored. These data provide a basis of comparison for studies that quantify hypoglycemia-related changes in fMRI activity during cognitive tasks based on visual stimuli and demonstrate that variations in blood glucose levels may modulate BOLD signals in the healthy brain.

Effects of hypoglycemia on human brain activation measured with fMRI. Publishing Authors By Initials

AW Anderson,RA Heptulla,N Driesen,D Flanagan,PA Goldberg,TW Jones,F Rife,H Sarofin,W Tamborlane,R Sherwin,JC Gore,

For similar nervous system: central nervous system: brain: prosencephalon: telencephalon: cerebrum: cerebral cortex: occipital lobe: visual cortex research abstracts see: nervous system: central nervous system: brain: prosencephalon: telencephalon: cerebrum: cerebral cortex: occipital lobe: visual cortex research

PUBMED ID PMID:

MEDLINE DATE:

Effects of hypoglycemia on human brain activation measured with fMRI. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Magnetic resonance imaging

VOLUME: 24

Page Numbers: 693-7

Journal Abbreviation:

ISSN: 0730-725X

DAY: 6

MONTH: 06

YEAR: 2006

Effects of hypoglycemia on human brain activation measured with fMRI. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8214883

Effects of hypoglycemia on human brain activation measured with fMRI. Keywords Mesh Terms:

KEYWORDS: Visual Cortex

MESH TERMS: physiopathology

Chemical & Substance for Abstract: Effects of hypoglycemia on human brain activation measured with fMRI. Information

Substance Name: Glucagon

Registry Number: 9007-92-5

Grant and Affiliation Information for Effects of hypoglycemia on human brain activation measured with fMRI.

AFFILIATION: Department of Biomedical Engineering, School of Engineering, Vanderbilt University, Nashville, TN 37232-2675, USA. adam.anderson@vanderbilt.edu

Country: United States

AGENCY: United States PHS

GRANT: MO1-00125

ACRONYM: EB

MEDLINETA: Magn Reson Imaging

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Effects of hypoglycemia on human brain activation measured with fMRI Related Publications

• A Phase II study of trabectedin single agent in patients with recurrent ovarian cancer previously treated with platinum-based regimens.
• A practical guide to robust detection of GABA in human brain by J-difference spectroscopy at 3 T using a standard volume coil.
• Adverse childhood experiences and mental health in young adults: a longitudinal survey.
• Amphibian emergency medicine.
• An Arabidopsis haplotype map takes root.
• Assessing functional connectivity in the human brain by fMRI.
• Assessing signal enhancement in distant dipolar field-based sequences.
• Calculation of RF Peak Power for 2D Arbitrary Shape Excitation in MRI.
• Comment on "Assessing functional connectivity in the human brain by fMRI".
• Comparison of a reference region model with direct measurement of an AIF in the analysis of DCE-MRI data.
• Detection and isolation of Japanese encephalitis virus from blood clots collected during the acute phase of infection.
• Development of 2dTCA for the detection of irregular, transient bold activity.
• Development of left occipitotemporal systems for skilled reading in children after a phonologically- based intervention.
• Effects of hypoglycemia on human brain activation measured with fMRI.
• Estrogenic environmental endocrine-disrupting chemical effects on reproductive neuroendocrine function and dysfunction across the life cycle.
• Hypoglycemia reduces the blood-oxygenation level dependent signal in primary auditory and visual cortex: a functional magnetic resonance imaging study.
• Integrating spatially resolved three-dimensional MALDI IMS with in vivo magnetic resonance imaging.
• Integration of quantitative DCE-MRI and ADC mapping to monitor treatment response in human breast cancer: initial results.
• Long-term trends in the use of coronary reperfusion strategies in acute myocardial infarction: a community-wide perspective.
• Molecular imaging of vascular endothelial growth factor receptor 2 expression using targeted contrast-enhanced high-frequency ultrasonography.
• Novel localization of NMDA receptors within neuroendocrine gonadotropin-releasing hormone terminals.
• Numerical study of water diffusion in biological tissues using an improved finite difference method.
• Optimization of MAGIC gel formulation for three-dimensional radiation therapy dosimetry.
• Quantitative magnetization transfer imaging via selective inversion recovery with short repetition times.
• Randomized adjuvant therapy trials in melanoma: surgical and systemic.
• Repeatability of a reference region model for analysis of murine DCE-MRI data at 7T.
• Serum glucose levels and hospital outcomes in patients with acute myocardial infarction without prior diabetes: a community-wide perspective.
• The effects of prenatal PCBs on adult female paced mating reproductive behaviors in rats.
• Tracking the migration of dendritic cells by in vivo optical imaging.
• Why endocrinologists need to take ownership of endocrine disruption.