Effects of GPi stimulation on human thalamic neuronal activity.

Effects of GPi stimulation on human thalamic neuronal activity. Research Abstract Details 

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Effects of GPi stimulation on human thalamic neuronal activity. Abstract Text:

Erwin B Montgomery,

OBJECTIVE: Determine the effects of globus pallidus interna (GPi) deep brain stimulation (DBS) on ventral oralis posterior nucleus of the thalamic (Vop) neuronal activity. METHODS: Microelectrode recordings in Vop during high frequency DBS GPi in a patient with dystonia. RESULTS: Twelve (48%) of 25 neurons in five locations neurons decreased their average discharge frequency, 2 (8%) increased and 11(44%) demonstrated no overall change. The patterns of responses were complex with periods of increase and decreased activity. All neurons were inhibited for the time period 3.5-5ms following the DBS pulse. Eighty-eight percent of neurons showed brief but highly consistent increases in the first 1ms following stimulation, 52% showed increased activities from 1.5 to 3ms. Twenty-four percent of neurons increased activity following inhibition. CONCLUSIONS: These findings are consistent with DBS activation of GPi axons to Vop and probable antidromic activation of Vop axons. SIGNIFICANCE: The physiological effects of DBS are far more complicated and will escape any theory that does not address the mechanisms of DBS as stimulation of a complex network of interactions. Further, the findings of post-inhibitory rebound increased raises questions about the role in inhibition in the current concepts of basal ganglia physiology.

Effects of GPi stimulation on human thalamic neuronal activity. Publishing Authors By Initials

EB Montgomery,

For similar natural sciences: time: time factors research abstracts see: natural sciences: time: time factors research

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Effects of GPi stimulation on human thalamic neuronal activity. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Clinical neurophysiology : official journal of the

VOLUME: 117

Page Numbers: 2691-702

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ISSN: 1388-2457

DAY: 6

MONTH: 10

YEAR: 2006

Effects of GPi stimulation on human thalamic neuronal activity. Information

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LANGUAGE: eng

NlmUniqueID: 100883319

Effects of GPi stimulation on human thalamic neuronal activity. Keywords Mesh Terms:

KEYWORDS: Time Factors

MESH TERMS: physiopathology

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Grant and Affiliation Information for Effects of GPi stimulation on human thalamic neuronal activity.

AFFILIATION: Department of Neurology, National Primate Research Center, University of Wisconsin-Madison, USA. montgomery@neurology.wisc.edu <montgomery@neurology.wisc.edu>

Country: Netherlands

AGENCY: United States NCRR

GRANT: 5P51 RR000167

ACRONYM: RR

MEDLINETA: Clin Neurophysiol

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