Effects of Ginkgo biloba on prevention of development of experimental diabetic nephropathy in rats.

Effects of Ginkgo biloba on prevention of development of experimental diabetic nephropathy in rats. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Effects of Ginkgo biloba on prevention of development of experimental diabetic nephropathy in rats. Abstract Text:

Qian Lu,Xiao-Xing Yin,Jian-Yun Wang,Yuan-Yuan Gao,Ying-Mei Pan,

AIM: To observe the preventive and therapeutic effects of Ginkgo biloba extract (GbE) on early experimental diabetic nephropathy (DN) in rats. METHODS: After an early DN model was induced by streptozotocin, rats were administered GbE at 3 doses for 12 weeks. Fasting blood glucose, creatinine (Cr), blood urea nitrogen (BUN), urine protein, kidney index, anti-oxidase, advanced glycosylation end products (AGE), collagen IV and laminin, matrix metalloproteinases-2 (MMP-2) and the tissue inhibitor of metalloproteinase-2 (TIMP-2), connective tissue growth factor (CTGF), and transforming growth factor-beta1 (TGF-beta1) mRNA were measured by different methods. The ultrastructural morphology and the thickness of glomerular base membrane (GBM) were observed by a transmission electron microscope. RESULTS: For the GbE-treated DN rats, when compared with the vehicle-treated DN rats, the fasting blood glucose level, Cr, BUN, urine protein level, and the intensity of oxidative stress were significantly decreased. The expression of MMP-2 greatly increased, and TIMP-2 decreased. Also, AGE, either in serum or in renal, the collagen IV, laminin, CTGF levels, and TGF-beta1 mRNA were reduced. Furthermore, both relative grades of mesangium hyperplasia by microscopical observation and the thickness of GBM by electron microscope measurement decreased significantly. CONCLUSION: GbE has protective effects on several pharmacological targets in the progress of DN and is a potential drug for the prevention of early DN.

Effects of Ginkgo biloba on prevention of development of experimental diabetic nephropathy in rats. Publishing Authors By Initials

Q Lu,XX Yin,JY Wang,YY Gao,YM Pan,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Effects of Ginkgo biloba on prevention of development of experimental diabetic nephropathy in rats. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Acta pharmacologica Sinica

VOLUME: 28

Page Numbers: 818-28

Journal Abbreviation: Acta Pharmacol. Sin.

ISSN: 1671-4083

DAY: 17

MONTH: Jun

YEAR: 2007

Effects of Ginkgo biloba on prevention of development of experimental diabetic nephropathy in rats. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 100956087

Effects of Ginkgo biloba on prevention of development of experimental diabetic nephropathy in rats. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Effects of Ginkgo biloba on prevention of development of experimental diabetic nephropathy in rats. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Effects of Ginkgo biloba on prevention of development of experimental diabetic nephropathy in rats.

AFFILIATION: Department of Pharmacy, Xuzhou Medical College, Xuzhou 221002, China.

Country: China

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Acta Pharmacol Sin

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Effects of Ginkgo biloba on prevention of development of experimental diabetic nephropathy in rats Related Publications

• Effects of degU32(Hy), degQa and degR pleiotropic regulatory genes on the growth and protease fermentation of Bacillus subtilis Ki-2-132.
• Region of interest reconstruction from truncated data in circular cone-beam CT.
• Screening for and genetic analysis on T-DNA-inserted mutant pool in rice.
• [A retrospective study on the complications after modified parotidectomy in benign tumors of parotid gland]
• [An experimental study on the antitumor effects induced by fusions of dendritic cells with NCI-H460 lung cancer cells]
• [Applications of tree-shaped structure in DICOM based on XML]
• [Cervical carcinoma in situ: a clinical and pathological analysis of 118 cases]
• [Clinical analysis of 32 cases of patients with severe asthma combined with acute left-sided heart failure]
• [Comparison of the diagnostic criteria of metabolic syndrome by International Diabetes Federation and that by Chinese Medical Association Diabetes Branch]
• [Construction and expression of various human prion proteins mutants with modified N-glycosylation sites in mammalian cells]
• [Determination of cadmium, cobalt, nickel in grain with Graphite Furnace Atomic Absorption Spectrometry]
• [Determination of chlorofluorocarbon residue in tobacco products by gas chromatography-electron capture detection]
• [Direct identification of Ophiogon japonicus (Thunb.)Ker-Gawl. from its confusable varieties by second derivative FTIR spectroscopy combined with statistics]
• [Experimental study on NK cells promoting donor marrow engraftment and hematopoietic reconstitution after MHC haploidentical BMT in mice]
• [Fractionation and spectroscopic property of dissolved organic matters in soils]
• [Implications of the pathogenic studies in patients with recurrent pulmonary tuberculosis]
• [Local application of bFGF and sucralfate during continuous tissue expansion]
• [Porcine acellular dermal matrix in the treatment of deep partial-thickness burns in human]
• [Primary study on Fas-mediated apoptosis in the liver tissue of patients with chronic hepatitis B]
• [Radiosensitization of beta-elemene on VX2 carcinoma transplanted on kidney in rabbits in vivo]
• [Spectral studies on nano-sized SO4(2-)/TiO2 photocatalyst prepared by hydrothermal heating the solution of Ti(SO4)2]
• [Spectroscopic study on procaine hydrochloride and its cyclodextrins inclusion complexes]
• [Studies on data compression of 1-D NMR spectra using wavelet transform]
• [Study on differentially expressed gene of the liver of treble fatty metabolism genes mutant mice using cDNA microarray]
• [Study on fluorescence quenching mechanism of HSA-PMA associated nanoparticle system]
• [Study on the photo-properties of 2-(2-substituted phenyl propenyl)-5-substituted benzoxazoles]
• [The alignment of the optical system for 216 coude focus echelle spectrometer]
• [The association of paraoxonase 2 gene C311S variant with ischemic stroke in Chinese type 2 diabetes mellitus patients]
• [The immune responses of the fusion protein consisted of two copies of T-cell and B-cell epitopes of food-and-mouth disease virus VP1 type O and LTB and STI enterotoxins of Escherichia coli]
• [The volume change of micronized acellular dermal matrix after injection]