[Effects of ginaton on the markers of myocardial injury during cardiopulmonary bypass]

[Effects of ginaton on the markers of myocardial injury during cardiopulmonary bypass] Research Abstract Details 

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[Effects of ginaton on the markers of myocardial injury during cardiopulmonary bypass] Abstract Text:

Yun-kun Deng,Fang Wei,Bang-quan An,Yun-kun Deng,Fang Wei,Bang-quan An,

OBJECTIVE: To evaluate the effects of Ginaton (Ginkgo biloba leaf extract) on the myocardial injury markers (MIMs) during cardiopulmonary bypass (CPB). METHODS: Forty patients with congenital heart diseases, scheduled to take atrial septum or ventricular septum repairing operation, were randomly divided into the Ginaton group and the control group, 20 cases in each group. Patients in both groups received St. Thomas' cardioplegic perfusion via radix aortae, while Ginaton (0.5 mg/kg) was added into the perfusion for the Ginton group. Cardiac surgery were started after complete heart arrest. Central venous blood was obtained before and at 0, 6th, 12th, 24th and 48th hour after operation for detection of serum C reaction protein (CRP) by immunoturbidimetry, as well as creation kinase-MB isoenzyme (CK-MB), cardiac troponin T (cTnT) and cardiac troponin I (cTnI) with enzyme-linked immunosorbent assay (ELISA). RESULTS: There was no difference in serum concentration of CRP, CK-MB, cTnT and cTnI between the two groups before operation (P > 0.05). These indexes increased immediately after operation in both groups ( P < 0.05). They reached the peak value 12 hrs after CPB and reduced to normal level 48 hrs post-operation in the control group, with the value significantly higher than that in the Ginaton group at all the corresponding time points (P < 0.05, or P < 0.01). CONCLUSION: Perfusion with Ginaton during CPB could significantly decrease the release of MIMs and improve post-CPB cardiac function recovery, exerting favorable myocardium-protective effects.

[Effects of ginaton on the markers of myocardial injury during cardiopulmonary bypass] Publishing Authors By Initials

YK Deng,F Wei,BQ An,YK Deng,F Wei,BQ An,

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[Effects of ginaton on the markers of myocardial injury during cardiopulmonary bypass] Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongx

VOLUME: 26

Page Numbers: 316-8

Journal Abbreviation: Zhongguo Zhong Xi Yi Jie He Za

ISSN: 1003-5370

DAY: 12

MONTH: Apr

YEAR: 2006

[Effects of ginaton on the markers of myocardial injury during cardiopulmonary bypass] Information

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LANGUAGE: chi

NlmUniqueID: 9211576

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AFFILIATION: Guizhou Provincial People's Hospital, Guiyang. dyk126@163.com

Country: China

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MEDLINETA: Zhongguo Zhong Xi Yi Jie He Za

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