Effects of gastric bypass and gastric banding on glucose kinetics and gut hormone release.

Effects of gastric bypass and gastric banding on glucose kinetics and gut hormone release. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Effects of gastric bypass and gastric banding on glucose kinetics and gut hormone release. Abstract Text:

Frédérique Rodieux,Vittorio Giusti,David A D'Alessio,Michel Suter,Luc Tappy,

Background:Bariatric surgery markedly improves glucose homeostasis in patients with type 2 diabetes even before any significant weight loss is achieved. Procedures that involve bypassing the proximal small bowel, such as Roux-en-Y gastric bypass (RYGBP), are more efficient than gastric restriction procedures such as gastric banding (GB).Objective:To evaluate the effects of RYGBP and GB on postprandial glucose kinetics and gastro-intestinal hormone secretion after an oral glucose load.Methods and Procedures:This study was a cross-sectional comparison among non-diabetic, weight-stable women who had undergone RYGBP (n = 8) between 9 and 48 months earlier or GB (n = 6) from 25 to 85 months earlier, and weight- and age-matched control subjects (n = 8). The women were studied over 4 h following ingestion of an oral glucose load. Total glucose and meal glucose kinetics were assessed using glucose tracers and plasma insulin, and gut hormone concentrations were simultaneously monitored.Results:Patients who had undergone RYGBP showed a a more rapid appearance of exogenous glucose in the systemic circulation and a shorter duration of postprandial hyperglycemia than patients who had undergone GB and C. The response in RYGBP patients was characterized by early and accentuated insulin response, enhanced postprandial levels of glucagon-like peptide-1 (GLP-1) and polypeptide YY (PYY), and greater postprandial suppression of ghrelin.Discussion:These findings indicate that RYGBP is associated with alterations in glucose kinetics and glucoregulatory hormone secretion. These alterations are probably secondary to the anatomic rearrangement of the foregut, given the fact that they are not observed after GB. Increased PYY and GLP-1 concentrations and enhanced ghrelin suppression are compatible with reduced food intake after RYGBP.Obesity (2008) 16, 298-305; doi:10.1038/oby.2007.83.

Effects of gastric bypass and gastric banding on glucose kinetics and gut hormone release. Publishing Authors By Initials

F Rodieux,V Giusti,DA D'Alessio,M Suter,L Tappy,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Effects of gastric bypass and gastric banding on glucose kinetics and gut hormone release. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Obesity (Silver Spring, Md.)

VOLUME: 16

Page Numbers: 298-305

Journal Abbreviation: Obesity (Silver Spring)

ISSN: 1930-7381

DAY: 1

MONTH: Feb

YEAR: 2008

Effects of gastric bypass and gastric banding on glucose kinetics and gut hormone release. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 101264860

Effects of gastric bypass and gastric banding on glucose kinetics and gut hormone release. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Effects of gastric bypass and gastric banding on glucose kinetics and gut hormone release. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Effects of gastric bypass and gastric banding on glucose kinetics and gut hormone release.

AFFILIATION: [1] 1Department of Physiology, University of Lausanne, Lausanne, Switzerland [2] 2Service of Endocrinology, Diabetology and Metabolism, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland.

Country: United States

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Obesity (Silver Spring)

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Effects of gastric bypass and gastric banding on glucose kinetics and gut hormone release Related Publications

• A high-fructose diet impairs basal and stress-mediated lipid metabolism in healthy male subjects.
• Blocking VLDL secretion causes hepatic steatosis but does not affect peripheral lipid stores or insulin sensitivity in mice.
• Counterregulatory responses to hypoglycemia in patients with maturity-onset diabetes of the young caused by HNF-1alpha gene mutations (MODY3).
• Effect of a thermogenic beverage on 24-hour energy metabolism in humans.
• Effects of four-week high-fructose diet on gene expression in skeletal muscle of healthy men.
• Effects of gastric bypass and gastric banding on glucose kinetics and gut hormone release.
• Glucose utilization and production in patients with maturity-onset diabetes of the young caused by a mutation of the hepatocyte nuclear factor-1alpha gene.
• Markedly blunted metabolic effects of fructose in healthy young female subjects compared with male subjects.
• Stress and metabolism.