Effects of fidarestat, an aldose reductase inhibitor, on nerve conduction velocity and bladder function in streptozotocin-treated female rats.

Effects of fidarestat, an aldose reductase inhibitor, on nerve conduction velocity and bladder function in streptozotocin-treated female rats. Research Abstract Details 

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Effects of fidarestat, an aldose reductase inhibitor, on nerve conduction velocity and bladder function in streptozotocin-treated female rats. Abstract Text:

Elena G Zotova,George J Christ,Weixin Zhao,Moses Tar,Srini D Kuppam,Joseph C Arezzo,

The effects of fidarestat, an aldose reductase inhibitor (ARI), were assessed on nerve conduction velocity (NCV) in somatic nerves and on multiple measures of bladder function in rats made hyperglycemic with streptozotocin (STZ) and in age-matched controls. Nerve conduction velocity was recorded at baseline and at 10, 20, 30, and 50 days after confirmation of the STZ-induced hyperglycemia in all rats (N=47); bladder function was assessed in a representative subset of rats (N=20) at Day 50. Caudal NCV was markedly slowed by STZ, and this effect was significantly reversed by fidarestat. The initial deficit and treatment-related improvement were especially evident for responses driven by high-frequency repetitive stimulation. Of the 11 parameters of bladder activity assessed, four measures-bladder capacity, micturition volume, micturition frequency, and bladder weight-were significantly different in the control and STZ-treated groups. These deficits were not affected by fidarestat. At Day 50, the induced deficits in bladder function were highly correlated with caudal NCV (r values ranging from 0.70 to 0.96; P values ranging from .02 to <.0001). These results suggested that fidarestat improved the slowing of somatic nerve NCV in hyperglycemic rats, but it was not effective in reversing associated bladder dysfunction, in spite of the highly significant correlation between these two diabetes-induced deficits. Possible explanations for this dissociation are discussed.

Effects of fidarestat, an aldose reductase inhibitor, on nerve conduction velocity and bladder function in streptozotocin-treated female rats. Publishing Authors By Initials

EG Zotova,GJ Christ,W Zhao,M Tar,SD Kuppam,JC Arezzo,

For similar reproductive and urinary physiology: urinary tract physiology: urination research abstracts see: reproductive and urinary physiology: urinary tract physiology: urination research

PUBMED ID PMID:

MEDLINE DATE: 2007 May-Jun

Effects of fidarestat, an aldose reductase inhibitor, on nerve conduction velocity and bladder function in streptozotocin-treated female rats. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Journal of diabetes and its complications

VOLUME: 21

Page Numbers: 187-95

Journal Abbreviation: J. Diabetes Complicat.

ISSN: 1056-8727

DAY: 3

MONTH: 12

YEAR: 2007

Effects of fidarestat, an aldose reductase inhibitor, on nerve conduction velocity and bladder function in streptozotocin-treated female rats. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9204583

Effects of fidarestat, an aldose reductase inhibitor, on nerve conduction velocity and bladder function in streptozotocin-treated female rats. Keywords Mesh Terms:

KEYWORDS: Urination

MESH TERMS: physiology

Chemical & Substance for Abstract: Effects of fidarestat, an aldose reductase inhibitor, on nerve conduction velocity and bladder function in streptozotocin-treated female rats. Information

Substance Name: Aldehyde Reductase

Registry Number: EC 1.1.1.21

Grant and Affiliation Information for Effects of fidarestat, an aldose reductase inhibitor, on nerve conduction velocity and bladder function in streptozotocin-treated female rats.

AFFILIATION: Department of Neurology, Albert Einstein College of Medicine, Yeshiva University, Bronx, NY 10461, USA.

Country: United States

AGENCY: United States NINDS

GRANT: 2R01 NS041194

ACRONYM: NS

MEDLINETA: J Diabetes Complications

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