Effects of external wrapping and increased blood flow on atrophy of the baboon iliac artery.

Effects of external wrapping and increased blood flow on atrophy of the baboon iliac artery. Research Abstract Details 

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Effects of external wrapping and increased blood flow on atrophy of the baboon iliac artery. Abstract Text:

OBJECTIVE: Increased blood flow causes neointimal atrophy, whereas relief of wall tension with an external wrap causes arterial medial atrophy. To study the effects of blood flow and wall tension separately and together, we applied tight or loose wraps on high-flow or normal-flow iliac arteries in baboons. METHOD: Baboon external iliac arteries were wrapped with loose-fitting and tight-fitting expanded polytetrafluoroethylene (ePTFE), leaving part unwrapped. A downstream arteriovenous fistula was constructed on one side to increase blood flow approximately twofold. The arteries were perfusion-fixed with 10% formalin after 4 (n = 5) and 28 days (n = 5). RESULTS: At 4 days, compared with the unwrapped artery, the loosely and tightly wrapped normal-flow artery showed significant medial atrophy (23% and 30%, respectively; P < .05). The tightly wrapped artery showed a loss of cells (27%; P = .02) but no change in cell density. At 28 days, the medial cross-sectional area was decreased by the tight wrap and loose wrap under normal (45% and 28%, respectively; P < .05) and high (43% and 29%, respectively; P < .05) flow. High flow did not alter the effect of wrapping nor did it affect the unwrapped medial area. At 28 days, the normal and high flow tightly wrapped media showed an insignificant loss of cells but had increased cell density (47% and 30%, respectively; P < .05), suggesting preferential loss of extracellular matrix. Decorin was expressed at the late time only in the tightly wrapped normal and high-flow media and was associated with tight packing of the collagen, as detected by picrosirius red staining. CONCLUSION: Loose-fitting and tight-fitting ePTFE wraps induced an inflammatory foreign body response that caused medial atrophy with loss of cells and extracellular matrix; the tight wrap was more effective. High blood flow did not prevent or augment medial atrophy.

Effects of external wrapping and increased blood flow on atrophy of the baboon iliac artery. Publishing Authors By Initials

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Effects of external wrapping and increased blood flow on atrophy of the baboon iliac artery. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Journal of vascular surgery : official publication

VOLUME: 47

Page Numbers: 1039-47

Journal Abbreviation: J. Vasc. Surg.

ISSN: 0741-5214

DAY: 21

MONTH: 03

YEAR: 2008

Effects of external wrapping and increased blood flow on atrophy of the baboon iliac artery. Information

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LANGUAGE: eng

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AFFILIATION: Department of Surgery, Seoul National University, Seoul, Korea.

Country: United States

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MEDLINETA: J Vasc Surg

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