Effects of experimental endogenous hyperlipemia on circulating leukocytes and erythrocytes.

Effects of experimental endogenous hyperlipemia on circulating leukocytes and erythrocytes. Research Abstract Details 

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Effects of experimental endogenous hyperlipemia on circulating leukocytes and erythrocytes. Abstract Text:

L A Ehrhart,A Butkus,A L Robertson,I H Page,

Effects of hyperlipemia on circulating leukocytes and erythrocytes were studied in dogs which were given repeated, intravenous injections of a nonionic detergent, Triton WR-1339.Erythrocyte lipid concentrations increased from 3.6+/-0.9 mg/10(10) cells in control animals to 9.3+/-1.5 mg in the hyperlipemic group. This increase was accompanied by a shift in the distribution of total fatty acids toward a higher percentage of saturated and monounsaturated acids. In contrast to the changes observed in erythrocytes, the leukocyte lipid content remained unaltered in dogs with serum cholesterol levels ranging from 500 to more than 2,000 mg/100 ml. Leukocyte counts rose whereas hematocrit values, hemoglobin concentrations, and erythrocyte counts decreased. Oxygen utilization studies showed no significant metabolic differences between leukocytes which were isolated from hyperlipemic or control animals. Circulating leukocytes in dogs with an endogenously induced hyperlipemia were shown therefore to maintain normal lipid concentrations and did not participate in lipophage formation, as reported for certain diet-induced lipemias.

Effects of experimental endogenous hyperlipemia on circulating leukocytes and erythrocytes. Publishing Authors By Initials

LA Ehrhart,A Butkus,AL Robertson,IH Page,

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Effects of experimental endogenous hyperlipemia on circulating leukocytes and erythrocytes. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Lipids

VOLUME: 3

Page Numbers: 84-7

Journal Abbreviation: Lipids

ISSN: 0024-4201

DAY: 6

MONTH: Jan

YEAR: 1968

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LANGUAGE: eng

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AFFILIATION: Research Division, The Cleveland Clinic Foundation, Cleveland, Ohio.

Country: United States

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MEDLINETA: Lipids

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