Effects of experimental acute tryptophan depletion on acoustic startle response in females.

Effects of experimental acute tryptophan depletion on acoustic startle response in females. Research Abstract Details 

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Effects of experimental acute tryptophan depletion on acoustic startle response in females. Abstract Text:

Christine Norra,Stefanie Becker,Sabine C Herpertz,Hanns Jürgen Kunert,Christine Norra,Stefanie Becker,Sabine C Herpertz, Kunert,

Previous studies suggest an important role for serotonergic (5-HT) modulation of the acoustic startle reflex (ASR) and prepulse inhibition (PPI). Acute challenge of brain serotonin by means of tryptophan depletion test (TDT) represents an established human challenge tool for temporary reduction of tryptophan (-TRP) levels and central nervous serotonin. Under these experimental conditions, PPI was found attenuated in males, but greater biochemical effects of TDT in the central nervous system of females are known. Therefore, in order to explore influence of 5-HT on various standard startle parameters in females, 16 young healthy females participated in a double-blind, cross-over TDT study. Acoustic stimuli were presented in 15 pulse-alone trials (100 dB, 40 ms) randomly followed by 25 pulse-alone or prepulse (70 dB, 30 ms; 120 ms interval) trials alongside electromyographic eyeblink recordings and mood state assessments. During 81% depletion of free plasma TRP, mean ASR magnitudes were significantly reduced compared to control (+TRP) condition while there were no differences in habituation or PPI nor did startle parameters correlate with mood states. Changes of plasma TRP and mood states correlated in tendency negatively in (-TRP) for depression and positively in (+TRP) for fatigue. In conclusion, this first study of startle parameters after TDT in a homogenous female population demonstrates that depletion of brain 5-HT in women only influences ASR.

Effects of experimental acute tryptophan depletion on acoustic startle response in females. Publishing Authors By Initials

C Norra,S Becker,SC Herpertz,HJ Kunert,C Norra,S Becker,SC Herpertz,HJ Kunert,

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Effects of experimental acute tryptophan depletion on acoustic startle response in females. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: European archives of psychiatry and clinical neuro

VOLUME: 258

Page Numbers: 1-9

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ISSN: 0940-1334

DAY: 27

MONTH: 09

YEAR: 2007

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LANGUAGE: eng

NlmUniqueID: 9103030

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Grant and Affiliation Information for Effects of experimental acute tryptophan depletion on acoustic startle response in females.

AFFILIATION: Department of Psychiatry and Psychotherapy, University Hospital RWTH, Aachen, Germany, norra@em.mpg.de.

Country: Germany

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MEDLINETA: Eur Arch Psychiatry Clin Neuro

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