[Effects of ethyl pyruvate on cell-mediated immune function in rats with delayed resuscitation after burn injury.]

[Effects of ethyl pyruvate on cell-mediated immune function in rats with delayed resuscitation after burn injury.] Research Abstract Details 

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[Effects of ethyl pyruvate on cell-mediated immune function in rats with delayed resuscitation after burn injury.] Abstract Text:

Yue-qing Dong,Yong-ming Yao,Peng Wei,Hui Liu,Ning Dong,Yan Yu,Zhi-yong Sheng,

OBJECTIVE: To investigate the effects of ethyl pyruvate (EP) on cell-mediated immune function in rats with delayed resuscitation after burn injury, and its potential regulatory mechanism. METHODS: Wistar rats were subjected to 30% full-thickness scald injury with delayed resuscitation. One hundred and three male rats were randomly divided into normal controls (n=7), sham scald group (n=32), scald group (n=32) in which 40 ml/kg normal saline was infused peritoneally 6 hours after scald, and EP treatment group (n=32) in which 40 mg/kg EP was injected peritoneally 6 hours after scald. Animals were sacrificed on postburn day 1, 3, 5, and 7, and spleen was collected to determine splenocyte proliferation, IL-2 production and cell-surface IL-2 receptor (IL-2R) expression. RESULTS: Splenic lymphocyte proliferation responses to T cell mitogen, concanavalin A (Con A), were depressed from 1 to 7 days after scald injury (all P<0.05). Meanwhile, in comparison with sham scald group, burn injury resulted in a significant decrease in splenic production of IL-2 on postburn day 1, 3, as well as 5, and a marked suppression of IL-2R expression on days 1 and 3 postburn (all P<0.05). Treatment with EP after burn injury showed a dramatic restoration of lymphocyte proliferation rate and increased production of IL-2 at various time points (all P<0.05). However, treatment with EP did not affect IL-2R expression compared with scalded rats (all P>0.05). CONCLUSION: Treatment with EP could markedly elevate splenic T lymphocyte proliferation response and increase production of IL-2 following burn injury, thereby improving cell-mediated immunity in thermally injured rats with delayed resuscitation.

[Effects of ethyl pyruvate on cell-mediated immune function in rats with delayed resuscitation after burn injury.] Publishing Authors By Initials

YQ Dong,YM Yao,P Wei,H Liu,N Dong,Y Yu,ZY Sheng,

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[Effects of ethyl pyruvate on cell-mediated immune function in rats with delayed resuscitation after burn injury.] Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Zhongguo wei zhong bing ji jiu yi xue = Chinese cr

VOLUME: 17

Page Numbers: 12-5

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ISSN: 1003-0603

DAY: 7

MONTH: Jan

YEAR: 2005

[Effects of ethyl pyruvate on cell-mediated immune function in rats with delayed resuscitation after burn injury.] Information

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LANGUAGE: chi

NlmUniqueID: 9887521

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AFFILIATION: Burns Institute, 304 th Clinical Department of General Hospital of PLA, Beijing 100037, China.

Country: China

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MEDLINETA: Zhongguo Wei Zhong Bing Ji Jiu

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