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[Effects of estrogen monotherapy on breast tissue in the primate model (Macaca fascicularis)]

[Effects of estrogen monotherapy on breast tissue in the primate model (Macaca fascicularis)] Research Abstract Details 

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  • [Effects of estrogen monotherapy on breast tissue in the primate model (Macaca fascicularis)] Abstract Text:

    d fothD Foth,j m clineJ M Cline,

    Much is unknown about the effects of estrogen's on the mammary gland in postmenopausal women today. In a recent study of estrogenmonotherapy 28 adult, surgically postmenopausal female monkeys (Macaca fascicularis) were treated continuously with estradiol or were given only a diet (control group). After 6 months serum levels of estradiol and progesterone, morphometrical, histopathological and immunohistochemical measurements of the mammary gland were performed. In monkeys receiving estradiol the mammary epithel thickness and the mammary epithelial area (as percentage of total breast area) increased. Estradiol induced mammary gland hyperplasia, but we did not see any atypical hyperplasia. Estradiol and progesterone receptors staining in mammary ducts and lobuli increased (not significant). Estradiol induced a mammary gland proliferation (not significant) shown as increased staining for PCNA and Ki67.

    [Effects of estrogen monotherapy on breast tissue in the primate model (Macaca fascicularis)] Publishing Authors By Initials

    d fothD Foth,jm clineJM Cline,

    For similar proteins: receptors, cytoplasmic and nuclear: receptors, steroid: receptors, progesterone research abstracts see: proteins: receptors, cytoplasmic and nuclear: receptors, steroid: receptors, progesterone research

    PUBMED ID PMID:

    MEDLINE DATE:

    [Effects of estrogen monotherapy on breast tissue in the primate model (Macaca fascicularis)] Journal Published:

    PUBLICATION TYPE: Journal Article

    Journal: Zentralblatt für Gynäkologie

    VOLUME: 119

    Page Numbers: 607-10

    Journal Abbreviation: Zentralbl Gynakol

    ISSN: 0044-4197

    DAY: 11

    MONTH: 02

    YEAR: 1997

    [Effects of estrogen monotherapy on breast tissue in the primate model (Macaca fascicularis)] Information

    Number of References:

    LANGUAGE: ger

    NlmUniqueID: 21820100

    [Effects of estrogen monotherapy on breast tissue in the primate model (Macaca fascicularis)] Keywords Mesh Terms:

    KEYWORDS: Receptors, Progesterone

    MESH TERMS: drug effects

    Chemical & Substance for Abstract: [Effects of estrogen monotherapy on breast tissue in the primate model (Macaca fascicularis)] Information

    Substance Name: Estradiol

    Registry Number: 50-28-2

    Grant and Affiliation Information for [Effects of estrogen monotherapy on breast tissue in the primate model (Macaca fascicularis)]

    AFFILIATION: Klinik und Poliklinik für Frauenheilkunde und Geburtshilfe, Ernst-Moritz-Arndt-Universität Greifswald.

    Country: GERMANY

    GERMANY Research PublicationGERMANY Research Publication

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    GRANT:

    ACRONYM:

    MEDLINETA: Zentralbl Gynakol

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