Effects of electro-acupuncture on CNTF expression in spared dorsal root ganglion and the associated spinal lamina II and nucleus dorsalis following adjacent dorsal root ganglionectomies in cats.

Effects of electro-acupuncture on CNTF expression in spared dorsal root ganglion and the associated spinal lamina II and nucleus dorsalis following adjacent dorsal root ganglionectomies in cats. Research Abstract Details 

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Effects of electro-acupuncture on CNTF expression in spared dorsal root ganglion and the associated spinal lamina II and nucleus dorsalis following adjacent dorsal root ganglionectomies in cats. Abstract Text:

Hao-Li Zhou,Lian-Shuang Zhang,Yan Kang,Wei Zhang,Ting-Hua Wang,

It is well known that plasticity occurs in deafferented spinal cord, and that electro-acupuncture (EA) could promote functional restoration. The underlying mechanism is, however, unknown. Ciliary neurotrophic factor (CNTF) plays a crucial role in neurite outgrowth and neuronal survival both in vivo and in vitro, and its expression might explain some of the mechanism. In this study, we investigated the effects of EA on CNTF expression in the spared L(6) dorsal root ganglion (DRG), and spinal lamina II at spinal segments L(3) and L(6) as well as nucleus dorsalis (ND) of L(3) spinal segment following removal of L(1)-L(5) and L(7)-S(2) (DRG) in the cat. After ganglionectomies, the total and small-to-medium-sized numbers of immunoreactive neurons decreased at 3dpo, and returned to the sham-operated level as early as 7dpo. After EA, immunoreactive neurons in L(6) DRG noticeably increased at 7dpo, compared with the non-acupunctured group. Notable increase in the large neurons was seen at 14dpo, while their numbers in L(3) and L(6) spinal cord segments significantly declined at 3dpo. Those in L(3) segment did not reach the sham-operated level until 14dpo, but their numbers in L(6) segment returned to the sham-operated level as early as 7dpo. CNTF immunopositive neurons in the ND of L(3) segment returned to the sham-operated level at 14dpo. After EA, their number significantly increased as early as 7dpo in lamina II of L(6) segment, and as late as 14dpo in ND of L(3) segment. Western blot analysis showed CNTF changes corresponding to those shown in immunohistochemical staining. It is concluded that CNTF expression was involved in the EA promoted plastic changes in L(6) DRG and the associated deafferented spinal lamina and ND.

Effects of electro-acupuncture on CNTF expression in spared dorsal root ganglion and the associated spinal lamina II and nucleus dorsalis following adjacent dorsal root ganglionectomies in cats. Publishing Authors By Initials

HL Zhou,LS Zhang,Y Kang,W Zhang,TH Wang,

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Effects of electro-acupuncture on CNTF expression in spared dorsal root ganglion and the associated spinal lamina II and nucleus dorsalis following adjacent dorsal root ganglionectomies in cats. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Neuropeptides

VOLUME: 42

Page Numbers: 95-106

Journal Abbreviation: Neuropeptides

ISSN: 0143-4179

DAY: 19

MONTH: 11

YEAR: 2007

Effects of electro-acupuncture on CNTF expression in spared dorsal root ganglion and the associated spinal lamina II and nucleus dorsalis following adjacent dorsal root ganglionectomies in cats. Information

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LANGUAGE: eng

NlmUniqueID: 8103156

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AFFILIATION: Institute of Neurological Disease, West China Hospital, Sichuan University, Chengdu 610041, China; Institute of Neuroscience, Kunming Medical College, Kunming 650031, China.

Country: Scotland

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