[Effects of efferent vagus nerve excitation on inflammatory response in heart tissue in rats with endotoxemia]

[Effects of efferent vagus nerve excitation on inflammatory response in heart tissue in rats with endotoxemia] Research Abstract Details 

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[Effects of efferent vagus nerve excitation on inflammatory response in heart tissue in rats with endotoxemia] Abstract Text:

De-guang Shi,Sen Hu,Xiao-guo Jiang,Dan Sun,Hua Jin,Jun-you Li,Qi-lin Liu,Zhi-yong Sheng,

OBJECTIVE: To study the effects of electrical stimulation of efferent vagus nerve on the inflammatory response in heart tissue in rats with endotoxemia. METHODS: Two hundred and ten Wistar rats were randomly divided into seven groups. Animals were subjected to bilateral cervical vagotomy, or a comparable sham surgical procedure in which the vagus nerves were isolated but not transected. The distal end of a vagus nerve trunk was placed across bipolar electrodes connected to a stimulation module and controlled by an acquisition system. Stimuli with constant voltage (5 V, 2 ms, 1 Hz) were applied to the nerve for 20 minutes immediately after administration of lipopolysaccharide (LPS, 10 mg/kg, E coli O111: B4, Sigma), and then were repeated 2 times after each of 10 minutes interval. Blood and tissue samples of these rats were collected at 1, 1.5 and 2 hours after LPS administration in all groups. Tumor necrosis factor-alpha (TNF-alpha) and mycloperoxidase (MPO) in heart tissue and serum MB isoenzyme of creatine kinase(CK-MB) were determined. RESULTS: The electrical stimulation of the efferent vagus nerve significantly decreased the contents of TNF-alpha and MPO in heart tissue and CK-MB in serum, and alleviated myocardial inflammation in heart tissue at all time points, especially at 1.5 hours after endotoxin challenge. CONCLUSION: The results suggested that excitation of the efferent vagus nerve can significantly alleviate the inflammatory response in the heart tissue, thus it might produce a potential protective effect on the heart during endotoxemia in rats.

[Effects of efferent vagus nerve excitation on inflammatory response in heart tissue in rats with endotoxemia] Publishing Authors By Initials

DG Shi,S Hu,XG Jiang,D Sun,H Jin,JY Li,QL Liu,ZY Sheng,

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[Effects of efferent vagus nerve excitation on inflammatory response in heart tissue in rats with endotoxemia] Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Zhongguo wei zhong bing ji jiu yi xue = Chinese cr

VOLUME: 15

Page Numbers: 26-8

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ISSN: 1003-0603

DAY: 10

MONTH: Jan

YEAR: 2003

[Effects of efferent vagus nerve excitation on inflammatory response in heart tissue in rats with endotoxemia] Information

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LANGUAGE: chi

NlmUniqueID: 9887521

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AFFILIATION: Burn Institute, 304th Hospital of People's Liberation Army, Beijing 100037, China.

Country: China

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MEDLINETA: Zhongguo Wei Zhong Bing Ji Jiu

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