Effects of different doses of atorvastatin on human apolipoprotein B-100, B-48, and A-I metabolism.

Effects of different doses of atorvastatin on human apolipoprotein B-100, B-48, and A-I metabolism. Research Abstract Details 

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Effects of different doses of atorvastatin on human apolipoprotein B-100, B-48, and A-I metabolism. Abstract Text:

Stefania Lamon-Fava,Margaret R Diffenderfer,P Hugh R Barrett,Aaron Buchsbaum,Nirupa R Matthan,Alice H Lichtenstein,Gregory G Dolnikowski,Katalin Horvath,Bela F Asztalos,Valeria Zago,Ernst J Schaefer,

Nine hypercholesterolemic and hypertriglyceridemic subjects were enrolled in a randomized, placebo-controlled, double-blind, crossover study to test the effect of atorvastatin 20 mg/day and 80 mg/day on the kinetics of apolipoprotein B-100 (apoB-100) in triglyceride-rich lipoprotein (TRL), intermediate density lipoprotein (IDL), and LDL, of apoB-48 in TRL, and of apoA-I in HDL. Compared with placebo, atorvastatin 20 mg/day was associated with significant reductions in TRL, IDL, and LDL apoB-100 pool size as a result of significant increases in fractional catabolic rate (FCR) without changes in production rate (PR). Compared with the 20 mg/day dose, atorvastatin 80 mg/day caused a further significant reduction in the LDL apoB-100 pool size as a result of a further increase in FCR. ApoB-48 pool size was reduced significantly by both atorvastatin doses, and this reduction was associated with nonsignificant increases in FCR. The lathosterol-campesterol ratio was decreased by atorvastatin treatment, and changes in this ratio were inversely correlated with changes in TRL apoB-100 and apoB-48 PR. No significant effect on apoA-I kinetics was observed at either dose of atorvastatin. Our data indicate that atorvastatin reduces apoB-100- and apoB-48-containing lipoproteins by increasing their catabolism and has a dose-dependent effect on LDL apoB-100 kinetics. Atorvastatin-mediated changes in cholesterol homeostasis may contribute to apoB PR regulation.

Effects of different doses of atorvastatin on human apolipoprotein B-100, B-48, and A-I metabolism. Publishing Authors By Initials

S Lamon-Fava,MR Diffenderfer,PH Barrett,A Buchsbaum,NR Matthan,AH Lichtenstein,GG Dolnikowski,K Horvath,BF Asztalos,V Zago,EJ Schaefer,

For similar lipids: glycerides: triglycerides research abstracts see: lipids: glycerides: triglycerides research

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Effects of different doses of atorvastatin on human apolipoprotein B-100, B-48, and A-I metabolism. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of lipid research

VOLUME: 48

Page Numbers: 1746-53

Journal Abbreviation: J. Lipid Res.

ISSN: 0022-2275

DAY: 27

MONTH: 05

YEAR: 2007

Effects of different doses of atorvastatin on human apolipoprotein B-100, B-48, and A-I metabolism. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 376606

Effects of different doses of atorvastatin on human apolipoprotein B-100, B-48, and A-I metabolism. Keywords Mesh Terms:

KEYWORDS: Triglycerides

MESH TERMS: metabolism

Chemical & Substance for Abstract: Effects of different doses of atorvastatin on human apolipoprotein B-100, B-48, and A-I metabolism. Information

Substance Name: Cholesterol

Registry Number: 57-88-5

Grant and Affiliation Information for Effects of different doses of atorvastatin on human apolipoprotein B-100, B-48, and A-I metabolism.

AFFILIATION: Lipid Metabolism Laboratory, Jean Mayer United States Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA. stefania.lamon-fava@tufts.edu

Country: United States

AGENCY: United States NIBIB

GRANT: P41 EB-00195

ACRONYM: EB

MEDLINETA: J Lipid Res

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