Effects of dendroaspis natriuretic Peptide on calcium-activated potassium current and its mechanism.

Effects of dendroaspis natriuretic Peptide on calcium-activated potassium current and its mechanism. Research Abstract Details 

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Effects of dendroaspis natriuretic Peptide on calcium-activated potassium current and its mechanism. Abstract Text:

Hui-Shu Guo,Yan-Zong Yang,Yuan Zou,Jing Xu,Zheng-Xu Cai,Qing-Hui Qi,

In this study, we sought to investigate the effect of dendroaspis natriuretic peptide (DNP) on calcium-activated potassium current (I(K(Ca))) and its mechanism in gastric antral circular smooth muscle cells (SMCs) using the whole-cell patch-clamp technique. DNP concentration-dependently increased macroscopic I(K(Ca)) and spontaneous transient outward currents (STOCs) in freshly isolated guinea pig gastric antral circular SMCs. The effects of DNP on I(K(Ca)) and/or STOCs were not blocked by applying calcium-free bath solution or the ryanodine receptor (RyR) antagonist ryanodine (10 microM), but they were inhibited by the inositol triphosphate receptor (IP(3)R) inhibitor heparin or the guanylate cyclase inhibitor LY83583. Moreover, a DNP-induced increase in STOCs was potentiated by the cyclic guanosine monophosphate (cGMP)-sensitive phosphoesterase inhibitor zaprinast. In conclusion, our results suggest that DNP increases I(K(Ca)) in gastric antral circular SMCs by increasing cGMP production and activating IP(3)Rs.

Effects of dendroaspis natriuretic Peptide on calcium-activated potassium current and its mechanism. Publishing Authors By Initials

HS Guo,YZ Yang,Y Zou,J Xu,ZX Cai,QH Qi,

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Effects of dendroaspis natriuretic Peptide on calcium-activated potassium current and its mechanism. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: The journal of physiological sciences : JPS

VOLUME: 58

Page Numbers: 1-6

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ISSN: 1880-6546

DAY: 22

MONTH: 12

YEAR: 2007

Effects of dendroaspis natriuretic Peptide on calcium-activated potassium current and its mechanism. Information

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LANGUAGE: eng

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Grant and Affiliation Information for Effects of dendroaspis natriuretic Peptide on calcium-activated potassium current and its mechanism.

AFFILIATION: Central Laboratory, The First Affiliated Hospital of Dalian Medical Universty, Dalian 116011, China. guohuishu1@yahoo.com.cn.

Country: Japan

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MEDLINETA: J Physiol Sci

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