Effects of deep brain stimulation on adaptive control of reaching.

Effects of deep brain stimulation on adaptive control of reaching. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Effects of deep brain stimulation on adaptive control of reaching. Abstract Text:

Haiyin Chen,Maurice Smith,Reza Shadmehr,

Lesion or degeneration of the cerebellum can profoundly impair adaptive control of reaching in humans. Computational models have proposed that internal models for motor action form in the cerebellum and influence planned motor output through the cerebello-thalamo-cortical pathway. However, lesions in the cerebellar thalamus have not been consistently shown to result in motor adaptation impairment. To elucidate the role of the cerebellar thalamus in humans, we studied a group of essential tremor (ET) patients with deep brain stimulation (DBS) electrodes placed in the cerebellar thalamus. The stimulation can be turned on or off remotely, and is thought to reduce tremor by blocking the spread of the pathological output from the cerebellum. We found that while thalamic DBS resulted in a dramatic reduction in ET, it also led to impaired motor adaptation in the patients. Thus, human adaptive reaching motor control depends on the integrity of the thalamic nucleus that relays cerebellar output to the cerebral cortex.

Effects of deep brain stimulation on adaptive control of reaching. Publishing Authors By Initials

H Chen,M Smith,R Shadmehr,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Effects of deep brain stimulation on adaptive control of reaching. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Conference proceedings : ... Annual International

VOLUME: 5

Page Numbers: 5445-8

Journal Abbreviation:

ISSN: 1557-170X

DAY: 6

MONTH: 02

YEAR: 2005

Effects of deep brain stimulation on adaptive control of reaching. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 101243413

Effects of deep brain stimulation on adaptive control of reaching. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Effects of deep brain stimulation on adaptive control of reaching. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Effects of deep brain stimulation on adaptive control of reaching.

AFFILIATION: Member, IEEE, Dept. of Biomedical Engineering, Johns Hopkins School of Medicine, 419 Traylor Building, 720 Rutland Ave, Baltimore, MD 21205 USA (Phone: 410-614-3424; fax: 410-614-9890; e-mail: haiyin@bme.jhu.edu).

Country: United States

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Conf Proc IEEE Eng Med Biol So

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Effects of deep brain stimulation on adaptive control of reaching Related Publications

• Adaptation and generalization in acceleration-dependent force fields.
• Adaptive control of saccades via internal feedback.
• Consolidation patterns of human motor memory.
• Dissociable effects of the implicit and explicit memory systems on learning control of reaching.
• Dissociating timing and coordination as functions of the cerebellum.
• Effects of deep brain stimulation on adaptive control of reaching.
• Evolution of motor memory during the seconds after observation of motor error.
• Generalization of motor learning depends on the history of prior action.
• Impairment of retention but not acquisition of a visuomotor skill through time-dependent disruption of primary motor cortex.
• Learning the dynamics of reaching movements results in the modification of arm impedance and long-latency perturbation responses.
• Motor adaptation as a process of reoptimization.
• Motor disorder in Huntington's disease begins as a dysfunction in error feedback control.
• Spontaneous recovery of motor memory during saccade adaptation.
• Towards a computational neuropsychology of action.