Effects of cyproterone acetate and carboxylic acid derivatives on the sebaceous glands of the Syrian hamster.

Effects of cyproterone acetate and carboxylic acid derivatives on the sebaceous glands of the Syrian hamster. Research Abstract Details 

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Effects of cyproterone acetate and carboxylic acid derivatives on the sebaceous glands of the Syrian hamster. Abstract Text:

The Syrian hamster ear model was used to study effects of the anti-androgen cyproterone acetate and of the anti-lipogenic compound 17beta-carboxylic acid methyl ester and its ethyl ester. The steroid derivatives were applied topically in a 1-2% concentration or given systemically. Response of sebaceous gland was measured by means of cell proliferation (3H-TdR autoradiography) and by gland size (histoplanimetry). Cyproterone acetate significantly reduced the labelling and the planimetric value, both topically and systemically. The carboxylic acid derivatives, which block the 5alpha-reductase were ineffective. The new animal model is a sensitive and suitable means to study inhibition of sebum production.

Effects of cyproterone acetate and carboxylic acid derivatives on the sebaceous glands of the Syrian hamster. Publishing Authors By Initials

For similar tissues: exocrine glands: sebaceous glands research abstracts see: tissues: exocrine glands: sebaceous glands research

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Effects of cyproterone acetate and carboxylic acid derivatives on the sebaceous glands of the Syrian hamster. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Archives for dermatological research. Archiv für d

VOLUME: 258

Page Numbers: 185-91

Journal Abbreviation:

ISSN: 0340-3696

DAY: 27

MONTH: Apr

YEAR: 1977

Effects of cyproterone acetate and carboxylic acid derivatives on the sebaceous glands of the Syrian hamster. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7512589

Effects of cyproterone acetate and carboxylic acid derivatives on the sebaceous glands of the Syrian hamster. Keywords Mesh Terms:

KEYWORDS: Sebaceous Glands

MESH TERMS: drug effects

Chemical & Substance for Abstract: Effects of cyproterone acetate and carboxylic acid derivatives on the sebaceous glands of the Syrian hamster. Information

Substance Name: Cyproterone

Registry Number: 2098-66-0

Grant and Affiliation Information for Effects of cyproterone acetate and carboxylic acid derivatives on the sebaceous glands of the Syrian hamster.

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Country: GERMANY, WEST

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MEDLINETA: Arch Dermatol Res

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