Effects of CYP2D6 polymorphisms on neuroleptic malignant syndrome.

Effects of CYP2D6 polymorphisms on neuroleptic malignant syndrome. Research Abstract Details 

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Effects of CYP2D6 polymorphisms on neuroleptic malignant syndrome. Abstract Text:

Daiji Kato,Chiaki Kawanishi,Ikuko Kishida,Taku Furuno,Kyoko Suzuki,Hideki Onishi,Yoshio Hirayasu,Daiji Kato,Chiaki Kawanishi,Ikuko Kishida,Taku Furuno,Kyoko Suzuki,Hideki Onishi,Yoshio Hirayasu,Daiji Kato,Chiaki Kawanishi,Ikuko Kishida,Taku Furuno,Kyoko Suzuki,Hideki Onishi,Yoshio Hirayasu,Daiji Kato,Chiaki Kawanishi,Ikuko Kishida,Taku Furuno,Kyoko Suzuki,Hideki Onishi,Yoshio Hirayasu,

OBJECTIVE: Neuroleptic malignant syndrome (NMS) is one of the most serious adverse reactions to antipsychotic medications. We accumulated data on Japanese NMS patients and, in a study designed to examine the effects of drug metabolism on the occurrence of NMS, tested the possibility of association between NMS and CYP2D6 polymorphisms. METHODS: We studied 53 patients who had experienced NMS and 112 healthy individuals. We determined what drugs the patients with NMS had been given and retrospectively identified candidates for drugs causing NMS. We screened the prevalence of CYP2D6 genotypes using polymerase chain reaction and restriction fragment length polymorphism analyses. RESULTS: The prevalence of *5 alleles in the group of all patients with NMS was higher than that in the controls, though this difference was not statistically significant (10.4% vs. 5.4%; P = 0.107; odds ratio (OR) 2.05; 95% confidence interval (CI) 0.87-4.80). No association was found between the frequency of *10 alleles and the occurrence of NMS. We found *4 and duplicated alleles in only one patient each among the patients with NMS. A total of 29 patients appeared to have developed NMS as a result of having taking CYP2D6 substrates. The prevalence of *5 alleles in these 29 patient was significantly higher than that in the controls (15.5% vs. 5.4%; P = 0.020; OR 3.25; 95% CI 1.30-8.13). CONCLUSION: Our findings suggest that the CYP2D6*5 allele is likely to affect vulnerability to development of NMS.

Effects of CYP2D6 polymorphisms on neuroleptic malignant syndrome. Publishing Authors By Initials

D Kato,C Kawanishi,I Kishida,T Furuno,K Suzuki,H Onishi,Y Hirayasu,D Kato,C Kawanishi,I Kishida,T Furuno,K Suzuki,H Onishi,Y Hirayasu,D Kato,C Kawanishi,I Kishida,T Furuno,K Suzuki,H Onishi,Y Hirayasu,D Kato,C Kawanishi,I Kishida,T Furuno,K Suzuki,H Onishi,Y Hirayasu,

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Effects of CYP2D6 polymorphisms on neuroleptic malignant syndrome. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: European journal of clinical pharmacology

VOLUME: 63

Page Numbers: 991-6

Journal Abbreviation: Eur. J. Clin. Pharmacol.

ISSN: 0031-6970

DAY: 14

MONTH: 08

YEAR: 2007

Effects of CYP2D6 polymorphisms on neuroleptic malignant syndrome. Information

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LANGUAGE: eng

NlmUniqueID: 1256165

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AFFILIATION: Department of Psychiatry, Yokohama City University School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama, Kanagawa, 236-0004, Japan, chiaki@yokohama-cu.ac.jp.

Country: Germany

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MEDLINETA: Eur J Clin Pharmacol

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