Effects of CoQ10 supplementation on plasma lipoprotein lipid, CoQ10 and liver and muscle enzyme levels in hypercholesterolemic patients treated with atorvastatin: a randomized double-blind study.

Effects of CoQ10 supplementation on plasma lipoprotein lipid, CoQ10 and liver and muscle enzyme levels in hypercholesterolemic patients treated with atorvastatin: a randomized double-blind study. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Effects of CoQ10 supplementation on plasma lipoprotein lipid, CoQ10 and liver and muscle enzyme levels in hypercholesterolemic patients treated with atorvastatin: a randomized double-blind study. Abstract Text:

Hiroshi Mabuchi,Atsushi Nohara,Junji Kobayashi,Masa-aki Kawashiri,Shoji Katsuda,Akihiro Inazu,Junji Koizumi, ,Hiroshi Mabuchi,Atsushi Nohara,Junji Kobayashi,Masa-aki Kawashiri,Shoji Katsuda,Akihiro Inazu,Junji Koizumi, ,

The long-term efficacy and safety of HMG-CoA reductase inhibitors (statins) have been established in large multicenter trials. Inhibition of this enzyme, however, results in decreased synthesis of cholesterol and other products downstream of mevalonate, such as CoQ10 or dolichol. This was a randomized double-blind, placebo-controlled study that examined the effects of CoQ10 and placebo in hypercholesterolemic patients treated by atorvastatin. Eligible patients were given 10mg/day of atorvastatin for 16 weeks. Half of the patients (n=24) were supplemented with 100mg/day of CoQ10, while the other half (n=25) were given the placebo. Serum LDL-C levels in the CoQ10 group decreased by 43%, while in the placebo group by 49%. The HDL-C increment was more striking in the CoQ10 group than in the placebo group. All patients showed definite reductions of plasma CoQ10 levels in the placebo group, by 42%. All patients supplemented with CoQ10 showed striking increases in plasma CoQ10 by 127%. In conclusion atorvastatin definitely decreased plasma CoQ10 levels and supplementation with CoQ10 increased their levels. These changes in plasma CoQ10 levels showed no relation to the changes in serum AST, ALT and CK levels. Further studies are needed, however, for the evaluation of CoQ10 supplementation in statin therapy.

Effects of CoQ10 supplementation on plasma lipoprotein lipid, CoQ10 and liver and muscle enzyme levels in hypercholesterolemic patients treated with atorvastatin: a randomized double-blind study. Publishing Authors By Initials

H Mabuchi,A Nohara,J Kobayashi,MA Kawashiri,S Katsuda,A Inazu,J Koizumi, ,H Mabuchi,A Nohara,J Kobayashi,MA Kawashiri,S Katsuda,A Inazu,J Koizumi, ,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Effects of CoQ10 supplementation on plasma lipoprotein lipid, CoQ10 and liver and muscle enzyme levels in hypercholesterolemic patients treated with atorvastatin: a randomized double-blind study. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Atherosclerosis

VOLUME: 195

Page Numbers: e182-9

Journal Abbreviation: Atherosclerosis

ISSN: 0021-9150

DAY: 6

MONTH: 08

YEAR: 2007

Effects of CoQ10 supplementation on plasma lipoprotein lipid, CoQ10 and liver and muscle enzyme levels in hypercholesterolemic patients treated with atorvastatin: a randomized double-blind study. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 242543

Effects of CoQ10 supplementation on plasma lipoprotein lipid, CoQ10 and liver and muscle enzyme levels in hypercholesterolemic patients treated with atorvastatin: a randomized double-blind study. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Effects of CoQ10 supplementation on plasma lipoprotein lipid, CoQ10 and liver and muscle enzyme levels in hypercholesterolemic patients treated with atorvastatin: a randomized double-blind study. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Effects of CoQ10 supplementation on plasma lipoprotein lipid, CoQ10 and liver and muscle enzyme levels in hypercholesterolemic patients treated with atorvastatin: a randomized double-blind study.

AFFILIATION: Department of Lipidology, Kanazawa University Graduate School of Medical Science, Takara-machi 13-1, Kanazawa 920-8641, Japan. mabuchi@med.kanazawa-u.ac.jp

Country: Ireland

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Atherosclerosis

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Effects of CoQ10 supplementation on plasma lipoprotein lipid, CoQ10 and liver and muscle enzyme levels in hypercholesterolemic patients treated with atorvastatin: a randomized double-blind study Related Publications

• A neural net for extracting knowledge from natural language data bases.
• Analysis of MPO-ANCA subtypes in a patient with propylthiouracil-induced vasculitis with multiple complications.
• CD8alpha alpha memory effector T cells descend directly from clonally expanded CD8alpha +beta high TCRalpha beta T cells in vivo.
• Case-control study on cigarette smoking and the risk of hepatocellular carcinoma among Japanese.
• Comparison of light intensity on the brain surface due to laser exposure during optical topography and solar irradiation.
• Development of an Optical Brain-machine Interface.
• Effects of CoQ10 supplementation on plasma lipoprotein lipid, CoQ10 and liver and muscle enzyme levels in hypercholesterolemic patients treated with atorvastatin: a randomized double-blind study.
• Expanded primary T nodules in the palatine tonsils from patients with IgA nephropathy.
• Fine-tuning of ENA gapmers as antisense oligonucleotides for sequence-specific inhibition.
• Hand Motion Estimation by EMG Signals Using Linear Multiple Regression Models.
• ISOLATION OF 2-PHENYLACETAMIDE, INDOLE-3-ACETAMIDE, AND INDOLE-3-CARBOXALDEHYDE FROM ETIOLATED SEEDLING OF PHASEOLUS.
• Identification of the binding region of basic calponin on alpha and beta tubulins.
• Neurotransmitters regulating vestibular commissural inhibition in the cat.
• Plateaus in the Dispersion of Two-Dimensional Magnetoplasmons in GaAs Quantum Wells: Theoretical Evidence of an Electron Reservoir.
• Portable electronic device.
• Portosystemic collaterals in portal hypertension: visualization by using blood-pool SPECT imaging.
• Quantitative study on phagocytosis of human tonsillar adherent cells by the flow cytometric and immunocytochemical methods.
• Relationship between expression of vascular endothelial growth factor in tumor tissue from gastric cancers and chemotherapy effects: comparison between S-1 alone and the combination of S-1 plus CDDP.
• Studies on neutral lipids and a new type of aldehydogenic ethanolamine phospholipid in Clostridium butyricum.
• Survey of airborne polyfluorinated telomers in keihan area, Japan.
• The endoscopic diagnosis of gastric cancer.
• Turnover rates of structural proteins of rabbit skeletal muscle.
• [A case of aortitis syndrome with left coronary ostial stenosis and aortic regurgitation treated by transaortic coronary endarterectomy and aortic valve replacement]
• [Left ventricular aneurysmectomy after myocardial infarction--comparative study between true aneurysms and functional aneurysms]
• [Pathological studies on supplying arteries to the conduction system in congenital heart disease, especially in the cases of ventricular septal defect and tetralogy of Fallot (author's transl)]
• [Physicians' function in primary health care]
• [Physiological function of the DCX family in brain development]
• [Raghib's syndrome associated with cor triatriatum--a rare surgical case report]
• [Surgical management of ventricular septal defect associated with malignant pulmonary hypertension]
• [Thoracic injuries--evaluation of injuries of the trachea, bronchi, and lung]