[Effects of clinorotation-induced weightlessness on growth factors and ERK signal transduction in cultured cardiac fibroblasts]

[Effects of clinorotation-induced weightlessness on growth factors and ERK signal transduction in cultured cardiac fibroblasts] Research Abstract Details 

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[Effects of clinorotation-induced weightlessness on growth factors and ERK signal transduction in cultured cardiac fibroblasts] Abstract Text:

Fen Yang,Ying-Hui Li,Yong-Jie Ma,Ping Zhong,Jin-ping Song,Zhong-quan Dai,

Objective: To study the changes of expression and secretion of some growth factors and ERK1/2 activation in cardiac fibroblasts under clinorotation conditions. Method: Primary cultured neonatal rat cardiac fibroblasts were clinorotated to simulate weightlessness. The bFGF and TGF(beta)1 expressions in the cells and Ang II concentration in the medium were detected by western blotting and radioimmunoassay respectively. The expression and phosphorylated level of ERK1/2 were analyzed by western blotting. Result: Compared to the control group, bFGF expression and Ang II concentration increased in clinorotation group, but there was no evident change in TGF(beta)1 expression. At the same time, the expression of ERK1/2 increased but their phosphorylated level decreased. Conclusion: Different growth factors responds to clinorotation by different ways. As one of the most important reactions of growth factor signal downstream pathways, ERK1/2 activation is inhibited in clinorotation.

[Effects of clinorotation-induced weightlessness on growth factors and ERK signal transduction in cultured cardiac fibroblasts] Publishing Authors By Initials

F Yang,YH Li,YJ Ma,P Zhong,JP Song,ZQ Dai,

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[Effects of clinorotation-induced weightlessness on growth factors and ERK signal transduction in cultured cardiac fibroblasts] Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Hang tian yi xue yu yi xue gong cheng = Space medi

VOLUME: 16 Suppl

Page Numbers: 532-7

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ISSN: 1002-0837

DAY: 28

MONTH: 02

YEAR: 2003

[Effects of clinorotation-induced weightlessness on growth factors and ERK signal transduction in cultured cardiac fibroblasts] Information

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LANGUAGE: chi

NlmUniqueID: 9425305

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AFFILIATION: Institute of Space Medico-Engineering, Beijing, China.

Country: China

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MEDLINETA: Space Med Med Eng (Beijing)

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