Effects of chronic unpredictable stress and methamphetamine on hippocampal glutamate function.

Effects of chronic unpredictable stress and methamphetamine on hippocampal glutamate function. Research Abstract Details 

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Effects of chronic unpredictable stress and methamphetamine on hippocampal glutamate function. Abstract Text:

Jamie Raudensky,Bryan K Yamamoto,

Although stress and methamphetamine (Meth) can independently and acutely affect glutamate transmission in the hippocampus, no studies have examined how chronic unpredictable stress modulates glutamate function and alters glutamate responsiveness to Meth. Therefore, the effects of chronic unpredictable stress on markers of glutamate function and subsequent Meth-induced increases in extracellular glutamate in the dorsal hippocampus were examined. Ten days of chronic unpredictable stress increased the plasmalemmal glial-glutamate transporter 2 (EAAT2) and increased vesicular glutamate transporter-1 (VGLUT1) immunoreactivity in a vesicle associated fraction. In addition, a 2-fold increase in vesicular glutamate content was observed. Chronic stress also enhanced Meth-induced increases in extracellular glutamate in the dorsal hippocampus in a TTX dependent manner. Overall, the finding that chronic stress resulted in an upregulation of glutamate function and an enhanced glutamate response to Meth may have implications for glutamate responsiveness in chronically stressed animals exposed to other challenges or stressors.

Effects of chronic unpredictable stress and methamphetamine on hippocampal glutamate function. Publishing Authors By Initials

J Raudensky,BK Yamamoto,

For similar proteins: carrier proteins: membrane transport proteins: ion pumps: antiporters: vesicular neurotransmitter transport proteins: vesicular glutamate transport proteins research abstracts see: proteins: carrier proteins: membrane transport proteins: ion pumps: antiporters: vesicular neurotransmitter transport proteins: vesicular glutamate transport proteins research

PUBMED ID PMID:

MEDLINE DATE:

Effects of chronic unpredictable stress and methamphetamine on hippocampal glutamate function. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Brain research

VOLUME: 1135

Page Numbers: 129-35

Journal Abbreviation: Brain Res.

ISSN: 0006-8993

DAY: 2

MONTH: 01

YEAR: 2007

Effects of chronic unpredictable stress and methamphetamine on hippocampal glutamate function. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 45503

Effects of chronic unpredictable stress and methamphetamine on hippocampal glutamate function. Keywords Mesh Terms:

KEYWORDS: Vesicular Glutamate Transport Proteins

MESH TERMS: metabolism

Chemical & Substance for Abstract: Effects of chronic unpredictable stress and methamphetamine on hippocampal glutamate function. Information

Substance Name: Glutamic Acid

Registry Number: 56-86-0

Grant and Affiliation Information for Effects of chronic unpredictable stress and methamphetamine on hippocampal glutamate function.

AFFILIATION: Boston University School of Medicine, Laboratory of Neurochemistry, Department of Pharmacology and Experimental Therapeutics L-613, 715 Albany St., Boston, MA 02118, USA.

Country: Netherlands

AGENCY: United States NIDA

GRANT: R01 DA016866-04

ACRONYM: DA

MEDLINETA: Brain Res

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