Effects of chronic choline and lecithin on mouse hippocampal dendritic spine density.

Effects of chronic choline and lecithin on mouse hippocampal dendritic spine density. Research Abstract Details 

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Effects of chronic choline and lecithin on mouse hippocampal dendritic spine density. Abstract Text:

Dendritic spines, which project from the dendrites of central neurons, are thought to contribute to the amount of contact area available for synaptic connections. The density of these spines has been found to correlate with learning and memory function, and there is a progressive decrease in dendritic spine density with aging. In addition, experimental animals given a choline-enriched diet have an increase in neocortical spine density compared to controls. In this study, the dendritic spine density of hippocampal pyramidal cells was examined in aged mice which had received life-long choline enriched, choline deficient or lecithin enriched diets. These treatments had no effect on hippocampal dendritic spine density compared to control. The results indicate that dietary supplementation may have different effects in different brain areas and that the relative increase in learning and memory function in aged animals given a choline or lecithin enriched diet is not due to an increase in hippocampal dendritic spine density.

Effects of chronic choline and lecithin on mouse hippocampal dendritic spine density. Publishing Authors By Initials

For similar animals: animal population groups: animals, inbred strains: mice, inbred strains research abstracts see: animals: animal population groups: animals, inbred strains: mice, inbred strains research

PUBMED ID PMID:

MEDLINE DATE: 1988 Summer-Aut

Effects of chronic choline and lecithin on mouse hippocampal dendritic spine density. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Experimental aging research

VOLUME: 14

Page Numbers: 137-41

Journal Abbreviation:

ISSN: 0361-073X

DAY: 25

MONTH: 02

YEAR: 2008

Effects of chronic choline and lecithin on mouse hippocampal dendritic spine density. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7603335

Effects of chronic choline and lecithin on mouse hippocampal dendritic spine density. Keywords Mesh Terms:

KEYWORDS: Mice, Inbred Strains

MESH TERMS: pharmacology

Chemical & Substance for Abstract: Effects of chronic choline and lecithin on mouse hippocampal dendritic spine density. Information

Substance Name: Choline

Registry Number: 62-49-7

Grant and Affiliation Information for Effects of chronic choline and lecithin on mouse hippocampal dendritic spine density.

AFFILIATION: Department of Pharmacology and Toxicology, University of Louisville School of Medicine, KY 40292.

Country: UNITED STATES

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MEDLINETA: Exp Aging Res

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