Effects of central injection of l-carnosine on sympathetic nerve activity innervating brown adipose tissue and body temperature in rats.

Effects of central injection of l-carnosine on sympathetic nerve activity innervating brown adipose tissue and body temperature in rats. Research Abstract Details 

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Effects of central injection of l-carnosine on sympathetic nerve activity innervating brown adipose tissue and body temperature in rats. Abstract Text:

Mamoru Tanida,Hitoshi Gotoh,Hiroyuki Taniguchi,Hiroto Otani,Jiao Shen,Takuo Nakamura,Nobuo Tsuruoka,Yoshinobu Kiso,Nobuaki Okumura,Katsuya Nagai,Mamoru Tanida,Hitoshi Gotoh,Hiroyuki Taniguchi,Hiroto Otani,Jiao Shen,Takuo Nakamura,Nobuo Tsuruoka,Yoshinobu Kiso,Nobuaki Okumura,Katsuya Nagai,

In the present study, using urethane-anesthetized rats, we examined the effects of intralateral cerebral ventricular (LCV) injection of various doses of l-carnosine on neural activity innervating brown adipose tissue (BAT-SNA) and body temperature (BT). We found that injection of a low dose of l-carnosine (0.01 mug) suppressed BAT-SNA significantly. Conversely, a high dose (100 mug) of l-carnosine significantly elevated BAT-SNA. In the light period (14:00), brown adipose tissue temperature (BAT-T) and BT were suppressed after low and elevated after high dose injection of l-carnosine whereas in the dark period (2:00), these parameters remained unchanged with l-carnosine treatment. Bilateral lesions of the hypothalamic suprachiasmatic nucleus (SCN) abolished the effects of low and high doses of l-carnosine on BAT-SNA, BAT-T and BT. Furthermore, high dose treatment with l-carnosine altered c-Fos induction in the SCN and the PVN. These results suggest that l-carnosine affects BAT-SNA, BAT-T and BT in a dose-dependent manner in the rat, and that the SCN may be involved in these effects.

Effects of central injection of l-carnosine on sympathetic nerve activity innervating brown adipose tissue and body temperature in rats. Publishing Authors By Initials

M Tanida,H Gotoh,H Taniguchi,H Otani,J Shen,T Nakamura,N Tsuruoka,Y Kiso,N Okumura,K Nagai,M Tanida,H Gotoh,H Taniguchi,H Otani,J Shen,T Nakamura,N Tsuruoka,Y Kiso,N Okumura,K Nagai,

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Effects of central injection of l-carnosine on sympathetic nerve activity innervating brown adipose tissue and body temperature in rats. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Regulatory peptides

VOLUME: 144

Page Numbers: 62-71

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ISSN: 0167-0115

DAY: 21

MONTH: 06

YEAR: 2007

Effects of central injection of l-carnosine on sympathetic nerve activity innervating brown adipose tissue and body temperature in rats. Information

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LANGUAGE: eng

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Grant and Affiliation Information for Effects of central injection of l-carnosine on sympathetic nerve activity innervating brown adipose tissue and body temperature in rats.

AFFILIATION: Institute for Protein Research, Osaka University, Suita, Osaka, 565-0871, Japan; ANBAS Corporation, Kita-ku, Osaka, 531-0072, Japan.

Country: Netherlands

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MEDLINETA: Regul Pept

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