Effects of cardiac resynchronization therapy on insulin-like growth factor-1 in patients with advanced heart failure.

Effects of cardiac resynchronization therapy on insulin-like growth factor-1 in patients with advanced heart failure. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Effects of cardiac resynchronization therapy on insulin-like growth factor-1 in patients with advanced heart failure. Abstract Text:

Giulio Molon,Edoardo Adamo,Gaetano M De Ferrari,Francesco Accardi,Eros Dalla Vecchia,Luciano Sallusti,Stefano Ciaffoni,Enrico Barbieri,Giulio Molon,Edoardo Adamo,Gaetano M De Ferrari,Francesco Accardi,Eros Dalla Vecchia,Luciano Sallusti,Stefano Ciaffoni,Enrico Barbieri,

BACKGROUND: Although a more favorable neurohormonal balance may contribute to improving symptoms following cardiac resynchronization therapy (CRT), no information is available regarding the effects of CRT on insulin-like growth factor-1 (IGF-1). This study assessed the effects of CRT on IGF-1 levels and their correlation with changes in quality of life and left ventricular (LV) function. METHODS AND RESULTS: Patients with cardiomyopathy in New York Heart Association class III or IV (n = 18; age 71 +/- 10 years), left ventricular ejection fraction (LVEF) < or = 40% and QRS > or = 130 ms or ventricular dyssynchrony were enrolled in the study and followed up for 6 months. After 3 months, there was an improvement in LVEF (from 29 +/- 7 to 33 +/- 10%, P = 0.0136) and quality of life (from 33 +/- 14 to 13 +/- 12, P = 0.0000) and an increase in IGF-1 levels (from 137 +/- 79 to 175 +/- 111 ng/ml, P = 0.01353). The change in quality of life correlated with changes in IGF-1 levels (P = 0.02) but not with LVEF changes. CONCLUSIONS: In patients with advanced heart failure, CRT leads to a significant increase in plasma IGF-1 levels within 3 months. This increase is correlated with the improvement in quality of life, whereas the increase in LVEF is not. This finding suggests that IGF-1 may play a role as a mediator in the early phase of symptomatic improvement after CRT.

Effects of cardiac resynchronization therapy on insulin-like growth factor-1 in patients with advanced heart failure. Publishing Authors By Initials

G Molon,E Adamo,GM De Ferrari,F Accardi,E Dalla Vecchia,L Sallusti,S Ciaffoni,E Barbieri,G Molon,E Adamo,GM De Ferrari,F Accardi,E Dalla Vecchia,L Sallusti,S Ciaffoni,E Barbieri,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Effects of cardiac resynchronization therapy on insulin-like growth factor-1 in patients with advanced heart failure. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Journal of cardiovascular medicine (Hagerstown, Md

VOLUME: 8

Page Numbers: 917-22

Journal Abbreviation:

ISSN: 1558-2027

DAY: 1

MONTH: Nov

YEAR: 2007

Effects of cardiac resynchronization therapy on insulin-like growth factor-1 in patients with advanced heart failure. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 101259752

Effects of cardiac resynchronization therapy on insulin-like growth factor-1 in patients with advanced heart failure. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Effects of cardiac resynchronization therapy on insulin-like growth factor-1 in patients with advanced heart failure. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Effects of cardiac resynchronization therapy on insulin-like growth factor-1 in patients with advanced heart failure.

AFFILIATION: Department of Cardiology, Sacro Cuore Hospital, don Calabria, Via don A. Sempreboni, Negrar, Verona, Italy. giulio.molon@sacrocuore.it

Country: United States

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: J Cardiovasc Med (Hagerstown)

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Effects of cardiac resynchronization therapy on insulin-like growth factor-1 in patients with advanced heart failure Related Publications

• A DENTAL STUDENT LOOKS AT THE PROFESSION.
• Analysis and chromosomal mapping of Leishmania (Leishmania) amazonensis amastigote expressed sequence tags.
• Antinociceptive activity of the N-methyl-D-aspartate receptor antagonist N-(2-Indanyl)-glycinamide hydrochloride (CHF3381) in experimental models of inflammatory and neuropathic pain.
• Association of botulinum neurotoxin serotypes a and B with synaptic vesicle protein complexes.
• Characterization of highly toxic type 2 ribosome-inactivating proteins from Adenia lanceolata and Adenia stenodactyla (Passifloraceae).
• Chromosomal localization and molecular characterization of three different 5S ribosomal DNA clusters in the sea urchin Paracentrotus lividus.
• Chromosome fragility in cattle with chronic enzootic haematuria.
• Comparison of operative and conservative treatment of fractures of the lower end of the femur involving the knee.
• Developmental origins of health and disease (DOHaD).
• Effects of cardiac resynchronization therapy on insulin-like growth factor-1 in patients with advanced heart failure.
• Factors associated with infant and adolescent mortality.
• Fat graft myringoplasty after unsuccessful tympanic membrane repair.
• Immunization with the cysteine proteinase Ldccys1 gene from Leishmania (Leishmania) chagasi and the recombinant Ldccys1 protein elicits protective immune responses in a murine model of visceral leishmaniasis.
• Intracellular localization of type III-delivered Pseudomonas ExoS with endosome vesicles.
• Intracellular trafficking of Pseudomonas ExoS, a type III cytotoxin.
• Local and systemic control in Ewing's sarcoma of the femur treated with chemotherapy, and locally by radiotherapy and/or surgery.
• Mechanism of substrate recognition by botulinum neurotoxin serotype A.
• Multiple pocket recognition of SNAP25 by botulinum neurotoxin serotype E.
• Multivariate classification and modeling in surface water pollution estimation.
• PSYCHOLOGY IN DENTAL PRACTICE.
• Plasma membrane localization affects the RhoGAP specificity of Pseudomonas ExoS.
• Racial inequalities and perinatal health in the southeast region of Brazil.
• Subunit Vaccine against the Seven Serotypes of Botulism.
• THYROGLOBULIN ANTIBODIES IN LEPROSY.
• The mortality impact of the August 2003 heat wave in France: Investigating the 'harvesting' effect and other long-term consequences.
• Why are the rates of cesarean section in Brazil higher in more developed cities than in less developed ones?
• [EVALUATION OF VARIOUS ENZYMATIC INDICES AND THE JIRGL TEST IN DIFFERENTIATION BETWEEN HEPATOCELLULAR AND CHOLOSTATIC JAUNDICE. II. APPLICATION OF DISCRIMINATING ANALYSES.]
• [Not Available.]
• [Not Available.]
• [Not Available.]