Effects of calmodulin antagonists on serine phospholipid base-exchange reaction in rabbit platelets.

Effects of calmodulin antagonists on serine phospholipid base-exchange reaction in rabbit platelets. Research Abstract Details 

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Effects of calmodulin antagonists on serine phospholipid base-exchange reaction in rabbit platelets. Abstract Text:

M Fujiwara,S Morikawa,S Taniguchi,K Mori,M Fujiwara,S Takaori,

Effects of the calmodulin antagonists chlorpromazine, trifluoperazine, and N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide on phospholipid metabolism were examined in rabbit platelets using [3H]serine, [3H]ethanolamine, [3H]choline, and [3H]glycerol. All these drugs markedly stimulated the incorporation of [3H]serine into phosphatidylserine. On the other hand, these drugs had only a slight effect on the rate of incorporation of [3H]ethanolamine and [3H]choline into the corresponding phospholipid. When [3H]glycerol was used as a precursor of the phospholipids, 3H-labeled phospholipids were mainly composed of phosphatidylcholine, phosphatidylethanolamine, and phosphatidylinositol. Although the phosphorus content of phosphatidylserine was about 40% of that of phosphatidylcholine in rabbit platelets, the amount of phosphatidylserine labeled with [3H]glycerol was less than 2% of that of the labeled phosphatidylcholine, and calmodulin antagonists slightly stimulated the incorporation of [3H]glycerol into phosphatidylserine. Treatment with calmodulin antagonists caused a marked decrease in the content of endogenous free serine with concomitant increase in the contents of endogenous free ethanolamine and choline. On the other hand, the contents of other free amino acids, including essential and non-essential amino acids, were unchanged. These results suggest that the calmodulin antagonists we used did not affect de novo synthesis of phosphatidylserine, but did stimulate the serine phospholipid base-exchange reaction in rabbit platelets.

Effects of calmodulin antagonists on serine phospholipid base-exchange reaction in rabbit platelets. Publishing Authors By Initials

M Fujiwara,S Morikawa,S Taniguchi,K Mori,M Fujiwara,S Takaori,

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Effects of calmodulin antagonists on serine phospholipid base-exchange reaction in rabbit platelets. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of biochemistry

VOLUME: 99

Page Numbers: 615-25

Journal Abbreviation: J. Biochem.

ISSN: 0021-924X

DAY: 19

MONTH: Mar

YEAR: 1986

Effects of calmodulin antagonists on serine phospholipid base-exchange reaction in rabbit platelets. Information

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LANGUAGE: eng

NlmUniqueID: 376600

Effects of calmodulin antagonists on serine phospholipid base-exchange reaction in rabbit platelets. Keywords Mesh Terms:

KEYWORDS: Tritium

MESH TERMS: diagnostic use

Chemical & Substance for Abstract: Effects of calmodulin antagonists on serine phospholipid base-exchange reaction in rabbit platelets. Information

Substance Name: Cytidine Diphosphate

Registry Number: 63-38-7

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Country: JAPAN

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MEDLINETA: J Biochem

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